EMD-26279

Helical reconstruction
2.7 Å
EMD-26279
3D View Gallery
Deposition: 19/02/2022
Map released: 23/03/2022
Last modified: 27/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-26279
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7u16 summary report (pdf.gz) Map and 7u16 FULL report (pdf.gz)
EMICSS annotations (xml)

TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).

EMD-26279

Helical reconstruction
2.7 Å
EMD-26279
3D View Gallery
Deposition: 19/02/2022
Map released: 23/03/2022
Last modified: 27/04/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB).
Fitted models: 7u16

Deposition Authors: Fitzpatrick AWP, Stowell MHB, Chang A , Xiang X , Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J , Heeman B, Forgrave LM, DeTure M, DeMarco ML , Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A , Xiang X , Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J , Heeman B, Forgrave LM, DeTure M, DeMarco ML , Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
(2022) Cell , 185 , 1346 - 1355.e15
PUBMED: 35247328
DOI: doi:10.1016/j.cell.2022.02.026
ISSN: 1097-4172