EMD-28523

Single-particle
3.4 Å
EMD-28523
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Deposition: 05/10/2022
Map released: 25/01/2023
Last modified: 25/01/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-28523
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8epa summary report (pdf.gz) Map and 8epa FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies

EMD-28523

Single-particle
3.4 Å
EMD-28523
3D View Gallery
Deposition: 05/10/2022
Map released: 25/01/2023
Last modified: 25/01/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Complex of IL2Rgamma extracellular domain with Fab fragments of antibodies REGN7257 and REGN9432
Fitted models: 8epa

Deposition Authors: Franklin MC , Romero Hernandez A
Blocking common gamma chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A , Nagashima K, Birchard D, Scott G, Ben LH , Ajithdoss D , Gayvert K , Romero Hernandez A , Herbin O , Tay A , Farrales P, Korgaonkar CK , Pan H, Shah S, Kamat V , Chatterjee I, Popke J , Oyejide A , Lim WK , Kim JH, Huang T , Franklin M , Olson W , Norton T , Perlee L, Yancopoulos GD, Murphy AJ , Sleeman MA , Orengo JM
(2023) Sci Transl Med , 15 , eabo0205 - eabo0205
PUBMED: 36630481
DOI: doi:10.1126/scitranslmed.abo0205
ISSN: 1946-6242