EMD-29714
Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2
EMD-29714
Single-particle2.2 Å
Deposition: 08/02/2023Map released: 08/03/2023
Last modified: 23/10/2024
Sample Organism:
Homo sapiens
Sample: Ternary complex of cullin ring E3 ubiquitin ligase substrate receptor arm (DDB1deltaB-DDA1-DCAF16) in compound-induced complex with bromodomain 2 of BRD4
Fitted models: 8g46
Deposition Authors: Ma MW
,
Hunkeler M ,
Jin CY,
Fischer ES
Sample: Ternary complex of cullin ring E3 ubiquitin ligase substrate receptor arm (DDB1deltaB-DDA1-DCAF16) in compound-induced complex with bromodomain 2 of BRD4
Fitted models: 8g46
Deposition Authors: Ma MW
,
Hunkeler M ,
Jin CY,
Fischer ES
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Li YD ,
Ma MW ,
Hassan MM ,
Hunkeler M ,
Teng M ,
Puvar K ,
Lumpkin R,
Sandoval B ,
Jin CY,
Ficarro SB,
Wang MY ,
Xu S,
Groendyke BJ ,
Sigua LH ,
Tavares I ,
Zou C,
Tsai JM ,
Park PMC ,
Yoon H ,
Majewski FC,
Marto JA ,
Qi J ,
Nowak RP ,
Donovan KA ,
Slabicki M ,
Gray NS ,
Fischer ES ,
Ebert BL
(2023) bioRxiv
,
Ma MW ,
Hassan MM ,
Hunkeler M ,
Teng M ,
Puvar K ,
Lumpkin R,
Sandoval B ,
Jin CY,
Ficarro SB,
Wang MY ,
Xu S,
Groendyke BJ ,
Sigua LH ,
Tavares I ,
Zou C,
Tsai JM ,
Park PMC ,
Yoon H ,
Majewski FC,
Marto JA ,
Qi J ,
Nowak RP ,
Donovan KA ,
Slabicki M ,
Gray NS ,
Fischer ES ,
Ebert BL
(2023) bioRxiv