EMD-31604
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex
EMD-31604
Single-particle3.1 Å
Deposition: 31/07/2021Map released: 23/02/2022
Last modified: 16/03/2022
Sample Organism:
Homo sapiens,
Bos taurus,
Rattus norvegicus,
synthetic construct
Sample: Cryo-EM structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with Peptide 20 and G protein
Fitted models: 7fin
Deposition Authors: Zhao F, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Sample: Cryo-EM structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with Peptide 20 and G protein
Fitted models: 7fin
Deposition Authors: Zhao F, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F,
Zhou Q,
Cong Z,
Hang K,
Zou X,
Zhang C,
Chen Y,
Dai A,
Liang A,
Ming Q,
Wang M,
Chen LN,
Xu P ,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057