EMD-42247

Single-particle
3.3 Å
EMD-42247
3D View Gallery
Deposition: 06/10/2023
Map released: 11/09/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-42247
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8uh6 summary report (pdf.gz) Map and 8uh6 FULL report (pdf.gz)
EMICSS annotations (xml)

Degrader-induced complex between PTPN2 and CRBN-DDB1

EMD-42247

Single-particle
3.3 Å
EMD-42247
3D View Gallery
Deposition: 06/10/2023
Map released: 11/09/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: CRBN-DDB1-PTPN2 complex
Fitted models: 8uh6

Deposition Authors: Catalano C , Bratkowski M , Scapin G, Hao Q
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
Hao Q , Rathinaswamy MK, Klinge KL, Bratkowski M , Mafi A, Baumgartner CK, Hamel KM, Veits GK, Jain R, Catalano C , Fitzgerald M, Hird AW, Park E, Vora HU, Henderson JA, Longenecker K, Hutchins CW, Qiu W, Scapin G, Sun Q, Stoll VS, Sun C, Li P, Eaton D , Stokoe D, Fisher SL, Nasveschuk CG , Paddock M, Kort ME
(2024) Commun Chem , 7 , 183 - 183
PUBMED: 39152201
DOI: doi:10.1038/s42004-024-01263-7
ISSN: 2399-3669