EMD-42676

Composite map
Single-particle
2.8 Å
EMD-42676
3D View Gallery
Deposition: 06/11/2023
Map released: 29/05/2024
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-42676
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8uwl summary report (pdf.gz) Map and 8uwl FULL report (pdf.gz)
EMICSS annotations (xml)

5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

EMD-42676

Composite map
Single-particle
2.8 Å
EMD-42676
3D View Gallery
Deposition: 06/11/2023
Map released: 29/05/2024
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: 5-HT2AR bound to Lisuride in complex with heterotrimeric mini-Gq protein and single-chain variable fragment (scFv16)
Fitted models: 8uwl

Deposition Authors: Barros-Alvarez X , Kim K , Panova O, Roth BL , Skiniotis G
AlphaFold2 structures guide prospective ligand discovery.
Lyu J , Kapolka N , Gumpper R, Alon A , Wang L , Jain MK , Barros-Alvarez X , Sakamoto K , Kim Y, DiBerto J , Kim K , Glenn IS , Tummino TA , Huang S, Irwin JJ , Tarkhanova OO , Moroz Y , Skiniotis G , Kruse AC , Shoichet BK , Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
PUBMED: 38753765
DOI: doi:10.1126/science.adn6354
ISSN: 1095-9203
ASTM: SCIEAS