EMD-9189
Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122
EMD-9189
Single-particle3.8 Å
Deposition: 06/10/2018Map released: 24/07/2019
Last modified: 29/07/2020
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1,
Macaca mulatta
Sample: DF1W-a.01 Fab bound to HIV-1 Env BG505 DS-SOSIP-VRC03 Fab- PGT122 Fab
Fitted models: 6mph
Deposition Authors: Acharya P, Xu K, Kwong PD
Sample: DF1W-a.01 Fab bound to HIV-1 Env BG505 DS-SOSIP-VRC03 Fab- PGT122 Fab
Fitted models: 6mph
Deposition Authors: Acharya P, Xu K, Kwong PD
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R,
Duan H 
,
Sheng Z,
Xu K,
Acharya P ,
Chen X,
Cheng C,
Dingens AS,
Gorman J,
Sastry M,
Shen CH,
Zhang B,
Zhou T,
Chuang GY,
Chao CW,
Gu Y,
Jafari AJ,
Louder MK,
O'Dell S,
Rowshan AP,
Viox EG,
Wang Y,
Choi CW,
Corcoran MM ,
Corrigan AR ,
Dandey VP,
Eng ET ,
Geng H,
Foulds KE,
Guo Y ,
Kwon YD,
Lin B,
Liu K,
Mason RD,
Nason MC,
Ohr TY,
Ou L,
Rawi R,
Sarfo EK ,
Schon A,
Todd JP,
Wang S,
Wei H,
Wu W,
Mullikin JC,
Bailer RT,
Doria-Rose NA,
Karlsson Hedestam GB,
Scorpio DG,
Overbaugh J,
Bloom JD,
Carragher B,
Potter CS,
Shapiro L,
Kwong PD,
Mascola JR
(2019) Cell , 178 , 567 - 584.e19
,
Sheng Z,
Xu K,
Acharya P ,
Chen X,
Cheng C,
Dingens AS,
Gorman J,
Sastry M,
Shen CH,
Zhang B,
Zhou T,
Chuang GY,
Chao CW,
Gu Y,
Jafari AJ,
Louder MK,
O'Dell S,
Rowshan AP,
Viox EG,
Wang Y,
Choi CW,
Corcoran MM ,
Corrigan AR ,
Dandey VP,
Eng ET ,
Geng H,
Foulds KE,
Guo Y ,
Kwon YD,
Lin B,
Liu K,
Mason RD,
Nason MC,
Ohr TY,
Ou L,
Rawi R,
Sarfo EK ,
Schon A,
Todd JP,
Wang S,
Wei H,
Wu W,
Mullikin JC,
Bailer RT,
Doria-Rose NA,
Karlsson Hedestam GB,
Scorpio DG,
Overbaugh J,
Bloom JD,
Carragher B,
Potter CS,
Shapiro L,
Kwong PD,
Mascola JR
(2019) Cell , 178 , 567 - 584.e19