The cryo-EM structure of hAE2 with bicarbonate
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8gvc
Q-score: 0.571
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ Pubmed: 37002221 DOI: doi:10.1038/s41467-023-37557-y ]
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- Bicarbonate ion (61 Da, Ligand)
- Hae2 with bicarbonate (137 kDa, Complex from Homo sapiens)
The asymmetry structure of hAE2
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8gve
Q-score: 0.509
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ DOI: doi:10.1038/s41467-023-37557-y Pubmed: 37002221 ]
- Anion exchange protein 2 (137 kDa, Complex from Homo sapiens)
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
The outward-facing structure of hAE2 in basic pH
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8gvf
Q-score: 0.56
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ DOI: doi:10.1038/s41467-023-37557-y Pubmed: 37002221 ]
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- Hae2 with bicarbonate (137 kDa, Complex from Homo sapiens)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8gvh
Q-score: 0.513
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ Pubmed: 37002221 DOI: doi:10.1038/s41467-023-37557-y ]
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Anion exchange protein 2 in acidic ph (137 kDa, Complex from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase in apo state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wta
Q-score: 0.265
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Pc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wtb
Q-score: 0.313
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Pc (Complex from Homo sapiens)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Pyruvate carboxylase (Protein from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7wtc
Q-score: 0.216
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)