He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8szf
Q-score: 0.587
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- Cinacalcet-bound active-state human calcium-sensing receptor casr dimer in lipid nanodiscs (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Spermine (202 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8szg
Q-score: 0.491
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Water (18 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Cinacalcet-bound human calcium-sensing receptor casr-gq complex in lipid nanodiscs (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8szh
Q-score: 0.572
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Extracellular calcium-sensing receptor (99 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Water (18 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Cinacalcet-bound human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8szi
Q-score: 0.51
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pam-free human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
- Extracellular calcium-sensing receptor (105 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m3e
Q-score: 0.563
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 455-459 [ DOI: doi:10.1038/s41586-021-03691-0 Pubmed: 34194040 ]
- Tryptophan (204 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human extracellular calcium-sensing receptor complexed with negative allosteric modulator nps-2143 under high calcium high trp condition (200 MDa, Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (101 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- 2-chloro-6-[(2r)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile (408 Da, Ligand)