The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8ijq
Q-score: 0.461
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8ijr
Q-score: 0.485
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) [ Pubmed: 38388831 DOI: doi:10.1038/s41594-024-01237-2 ]
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine (Complex from Homo sapiens)
- Sphingomyelin synthase-related protein 1 (48 kDa, Protein from Homo sapiens)
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
- (2s)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11z)-octadec-11-enoate (594 Da, Ligand)
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8w9w
Q-score: 0.377
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) [ Pubmed: 38388831 DOI: doi:10.1038/s41594-024-01237-2 ]
- ~{n}-[(~{z},2~{s},3~{r})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide (467 Da, Ligand)
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine (Complex from Homo sapiens)
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
- Sphingomyelin synthase-related protein 1 (31 kDa, Protein from Homo sapiens)
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7y4w
Q-score: 0.367
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ DOI: doi:10.1126/sciadv.adi5656 Pubmed: 37831771 ]
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Derlin-1 (26 kDa, Protein from Homo sapiens)
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7y53
Q-score: 0.366
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ Pubmed: 37831771 DOI: doi:10.1126/sciadv.adi5656 ]
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Derlin-1 (26 kDa, Protein from Homo sapiens)
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 4.51 Å
EM Method: Single-particle
Fitted PDBs: 7y59
Q-score: 0.22
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ Pubmed: 37831771 DOI: doi:10.1126/sciadv.adi5656 ]
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Derlin-1 (30 kDa, Protein from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wtb
Q-score: 0.313
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Pc (Complex from Homo sapiens)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7wtc
Q-score: 0.216
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wtd
Q-score: 0.226
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ Pubmed: 36283412 DOI: doi:10.1016/j.molcel.2022.09.033 ]
- Pc (Complex from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wte
Q-score: 0.36
Chai P, Lan P, Li S, Yao D, Chang C, Cao M, Shen Y, Ge S, Wu J, Lei M, Fan X
Mol Cell (2022) 82 pp. 4116-4130.e6 [ DOI: doi:10.1016/j.molcel.2022.09.033 Pubmed: 36283412 ]
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from human)
- Acetyl coenzyme *a (809 Da, Ligand)
- Pc (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)