Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Cavadini S" AND xref_links:"cpx" AND author_orcid:"0000-0002-7682-0967" AND resolution:[4 TO 5}

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EMD-17160

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Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement)

Release date: May 24, 2023
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 8osl
Q-score: 0.177

Michael AK, Stoos L, Crosby P, Eggers N, Nie XY, Makasheva K, Minnich M, Healy KL, Weiss J, Kempf G, Cavadini S, Kater L, Seebacher J, Vecchia L, Chakraborty D, Isbel L, Grand RS, Andersch F, Fribourgh JL, Schubeler D, Zuber J, Liu AC, Becker PB, Fierz B, Partch CL, Menet JS, Thoma NH

Nature (2023) 619 pp. 385-393 [ DOI: doi:10.1038/s41586-023-06282-3 Pubmed: 37407816 ]

Sample:

Histone octamer (Complex from Homo sapiens)
Nucleosomal dna (Complex from synthetic construct)
Clock-bmal1 bound to a nucleosome at shl -6.2 (Complex)
Dna (147-mer) (45 kDa, DNA from Homo sapiens)
Clock-bmal1 heterodimer (Complex from Mus musculus)
Nucleosome core particle (Complex)
Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
Histone h4 (11 kDa, Protein from Homo sapiens)
Dna (147-mer) (45 kDa, DNA from Homo sapiens)
Histone h3.1 (15 kDa, Protein from Homo sapiens)
Histone h2b type 1-j (14 kDa, Protein from Homo sapiens)
Basic helix-loop-helix arnt-like protein 1 (43 kDa, Protein from Mus musculus)
Circadian locomoter output cycles protein kaput (43 kDa, Protein from Mus musculus)

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