Wildtype rat TRPV2 in nanodiscs bound to RR and 2-APB
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ffm
Q-score: 0.606
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
- Tetramer of wildtype rat trpv2 in nanodiscs bound to ruthenium red (340 kDa, Complex from Rattus norvegicus)
RR-bound wildtype rabbit TRPV5 in nanodiscs
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8ffn
Q-score: 0.577
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- Tetramer of wildtype rabbit trpv5 in nanodiscs bound to ruthenium red (335 kDa, Complex from Oryctolagus cuniculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8ffq
Q-score: 0.624
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ Pubmed: 38225355 DOI: doi:10.1038/s44319-023-00050-0 ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- Tetramer of wildtype rabbit trpv5 into nanodiscs in complex with ruthenium red and pi(4,5)p2 (335 kDa, Complex from Oryctolagus cuniculus)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Ergosterol (396 Da, Ligand)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
Wildtype rabbit TRPV5 into nanodiscs in Apo state
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8tf2
Q-score: 0.634
De Jesus-Perez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY
Structure (2024) 32 pp. 148-156.e5 [ Pubmed: 38141613 DOI: doi:10.1016/j.str.2023.11.012 ]
- Ergosterol (396 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Tetramer of wildtype rabbit trpv5 into nanodiscs in apo state (335 kDa, Complex from Oryctolagus cuniculus)
Wildtype rabbit TRPV5 into nanodiscs in complex with econazole
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8tf3
Q-score: 0.571
De Jesus-Perez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY
Structure (2024) 32 pp. 148-156.e5 [ DOI: doi:10.1016/j.str.2023.11.012 Pubmed: 38141613 ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Tetramer of wildtype rabbit trpv5 into nanodiscs in complex with econazole (335 kDa, Complex from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- 1-[(2s)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole (381 Da, Ligand)
Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8tf4
Q-score: 0.584
De Jesus-Perez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY
Structure (2024) 32 pp. 148-156.e5 [ Pubmed: 38141613 DOI: doi:10.1016/j.str.2023.11.012 ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- Tetramer of wildtype rabbit trpv5 into nanodiscs in the presence of pi(4,5)p2 and econazole (335 kDa, Complex from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1-[(2s)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole (381 Da, Ligand)
Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ffo
Q-score: 0.498
Lee BH, De Jesus Perez JJ, Moiseenkova-Bell V, Rohacs T
Nat Commun (2023) 14 pp. 5883-5883 [ Pubmed: 37735536 DOI: doi:10.1038/s41467-023-41577-z ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Ergosterol (396 Da, Ligand)
- Tetramer of wildtype rabbit trpv5 in nanodiscs in complex with pi(4,5)p2 (335 kDa, Complex from Oryctolagus cuniculus)
Wildtype rabbit TRPV5 in nanodiscs in the presence of oleoyl coenzyme A, Closed stated
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8fhh
Q-score: 0.554
Lee BH, De Jesus Perez JJ, Moiseenkova-Bell V, Rohacs T
Nat Commun (2023) 14 pp. 5883-5883 [ Pubmed: 37735536 DOI: doi:10.1038/s41467-023-41577-z ]
- Tetramer of wildtype rabbit trpv5 in nanodiscs in the presence of oleoyl coenzyme a (335 kDa, Complex from Oryctolagus cuniculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8fhi
Q-score: 0.504
Lee BH, De Jesus Perez JJ, Moiseenkova-Bell V, Rohacs T
Nat Commun (2023) 14 pp. 5883-5883 [ Pubmed: 37735536 DOI: doi:10.1038/s41467-023-41577-z ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Tetramer of wildtype rabbit trpv5 in nanodiscs in complex with oleoyl coenzyme a (335 kDa, Complex from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)