Electron Microscopy Data Bank

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Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain native virion

Release date: Jan. 25, 2023
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 7t9p
Q-score: 0.789

Lane T, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser S, Frost J, Rudy M, Tyler K, Klose T, Kuhn RJ, Makarov V, Ekins S

To Be Published

Sample:

Enterovirus d68 (Virus from enterovirus D68)
Viral protein 4 (7 kDa, Protein from enterovirus D68)
Viral protein 2 (26 kDa, Protein from enterovirus D68)
Viral protein 1 (32 kDa, Protein from enterovirus D68)
Viral protein 3 (27 kDa, Protein from enterovirus D68)

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EMD-25772

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Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with inhibitor 11526092

Release date: Jan. 25, 2023
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 7taf
Q-score: 0.779

Lane T, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser S, Frost J, Rudy M, Tyler K, Klose T, Kuhn RJ, Makarov V, Ekins S

To Be Published

Sample:

Enterovirus d68 (Virus from enterovirus D68)
Viral protein 4 (7 kDa, Protein from enterovirus D68)
Viral protein 2 (26 kDa, Protein from enterovirus D68)
Viral protein 1 (32 kDa, Protein from enterovirus D68)
Viral protein 3 (27 kDa, Protein from enterovirus D68)
N,n-dimethyl-5-(3-{2-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy}propyl)-1,2-oxazole-3-carboxamide (424 Da, Ligand)

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EMD-25773

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Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with pleconaril

Release date: Jan. 25, 2023
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7tag
Q-score: 0.659

Lane T, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser S, Frost J, Rudy M, Tyler K, Klose T, Kuhn RJ, Makarov V, Ekins S

To Be Published

Sample:

Enterovirus d68 (Virus from enterovirus D68)
Viral protein 4 (7 kDa, Protein from enterovirus D68)
Viral protein 2 (26 kDa, Protein from enterovirus D68)
Viral protein 1 (32 kDa, Protein from enterovirus D68)
Viral protein 3 (27 kDa, Protein from enterovirus D68)
3-{3,5-dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole (381 Da, Ligand)

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EMD-25774

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Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain in complex with inhibitor 11526091 (no/low occupancy-no inhibitor modeled)

Release date: Jan. 25, 2023
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7tah
Q-score: 0.707

Lane T, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser S, Frost J, Rudy M, Tyler K, Klose T, Kuhn RJ, Makarov V, Ekins S

To Be Published

Sample:

Enterovirus d68 (Virus from enterovirus D68)
Viral protein 4 (7 kDa, Protein from enterovirus D68)
Viral protein 2 (26 kDa, Protein from enterovirus D68)
Viral protein 1 (32 kDa, Protein from enterovirus D68)
Viral protein 3 (27 kDa, Protein from enterovirus D68)

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EMD-25776

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Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain in complex with inhibitor 11526093 (no/low occupancy-no inhibitor modeled)

Release date: Jan. 25, 2023
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 7taj
Q-score: 0.769

Lane T, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser S, Frost J, Rudy M, Tyler K, Klose T, Kuhn RJ, Makarov V, Ekins S

To Be Published

Sample:

Enterovirus d68 (Virus from enterovirus D68)
Viral protein 4 (7 kDa, Protein from enterovirus D68)
Viral protein 2 (26 kDa, Protein from enterovirus D68)
Viral protein 1 (32 kDa, Protein from enterovirus D68)
Viral protein 3 (27 kDa, Protein from enterovirus D68)

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EMD-32575

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CVB5 expended empty particle

Release date: March 30, 2022
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 7wl3
Q-score: 0.566

Yang P, Shi D, Fu J, Zhang L, Chen R, Zheng B, Wang X, Xu S, Zhu L, Wang K

J Virol (2022) 96 pp. e0010522-e0010522 [ DOI: doi:10.1128/jvi.00105-22 Pubmed: 35442060 ]

Sample:

Coxsackievirus b5 (Virus from Coxsackievirus B5)
Genome polyprotein (27 kDa, Protein from Coxsackievirus B5)
Capsid protein (25 kDa, Protein from Coxsackievirus B5)
Genome polyprotein (26 kDa, Protein from Coxsackievirus B5)

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EMD-33101

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CVB5-intermediate altered particle containing VP1/VP2/VP3 and RNA genome

Release date: March 30, 2022
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7xb2
Q-score: 0.576

Yang P, Shi D, Fu J, Zhang L, Chen R, Zheng B, Wang X, Xu S, Zhu L, Wang K

J Virol (2022) 96 pp. e0010522-e0010522 [ DOI: doi:10.1128/jvi.00105-22 Pubmed: 35442060 ]

Sample:

Coxsackievirus b5 (Virus from Coxsackievirus B5)
Genome polyprotein (26 kDa, Protein from Coxsackievirus B5)
Genome polyprotein (27 kDa, Protein from Coxsackievirus B5)
Genome polyprotein (26 kDa, Protein from Coxsackievirus B5)

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EMD-30443

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human KCNQ2 in apo state

Release date: Sept. 16, 2020
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7cr0
Q-score: 0.507

Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J

Cell Res (2021) 31 pp. 52-61 [ DOI: doi:10.1038/s41422-020-00410-8 Pubmed: 32884139 ]

Sample:

Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Voltage-gated potassium channel kcnq2 (Complex from Homo sapiens)

EMD-30444

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human KCNQ2 in complex with ztz240

Release date: Sept. 16, 2020
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7cr1
Q-score: 0.491

Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J

Cell Res (2021) 31 pp. 52-61 [ DOI: doi:10.1038/s41422-020-00410-8 Pubmed: 32884139 ]

Sample:

Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Voltage-gated potassium channel kcnq2 (Complex from Homo sapiens)
N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide (250 Da, Ligand)

EMD-30445

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human KCNQ2 in complex with retigabine

Release date: Sept. 16, 2020
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cr2
Q-score: 0.452

Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J

Cell Res (2021) 31 pp. 52-61 [ DOI: doi:10.1038/s41422-020-00410-8 Pubmed: 32884139 ]

Sample:

Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Ethyl n-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate (303 Da, Ligand)
Voltage-gated potassium channel kcnq2 (Complex from Homo sapiens)

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