Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 6x3s
Q-score: 0.531
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ Pubmed: 32879488 DOI: doi:10.1038/s41586-020-2654-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with bicuculline (Complex from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- (5s)-6,6-dimethyl-5-[(6r)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium (382 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 6x3t
Q-score: 0.642
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2,6-bis(1-methylethyl)phenol (178 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and propofol (Complex from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3u
Q-score: 0.462
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil (Complex)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3v
Q-score: 0.527
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Etomidate (244 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and etomidate (Complex from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6x3w
Q-score: 0.528
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and phenobarbital (Complex)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- 5-ethyl-5-phenylpyrimidine-2,4,6(1h,3h,5h)-trione (232 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 6x3x
Q-score: 0.554
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and diazepam (Complex)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6x3z
Q-score: 0.497
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ Pubmed: 32879488 DOI: doi:10.1038/s41586-020-2654-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba (Complex from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 6x40
Q-score: 0.549
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and picrotoxin (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6pv8
Q-score: 0.416
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Igg2b heavy chain (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to at-1001 (Complex from Homo sapiens)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- (3-endo)-n-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (309 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Kappa fab light chain (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501-511.e6 [ Pubmed: 31488329 DOI: doi:10.1016/j.neuron.2019.07.030 ]