EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

Edit your search query here and hit Return to execute it:

author:"Hibbs RE" AND author_orcid:"0000-0003-4390-8556" AND author_orcid:"0000-0002-8939-8988" AND xref_links:"interpro" AND author_name:"Teng J" AND author_name:"Zaveri NT"

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EMDB [1]

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EMD-20488

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Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Release date: Sept. 11, 2019
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6pv8
Q-score: 0.416

Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE

Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]

Sample:

Kappa fab light chain (23 kDa, Protein from house mouse)
Igg2b heavy chain (Complex)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to at-1001 (Complex from Homo sapiens)
Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
Igg2b fab heavy chain (23 kDa, Protein from house mouse)
(3-endo)-n-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (309 Da, Ligand)
Cholesterol hemisuccinate (486 Da, Ligand)
Water (18 Da, Ligand)
Igg2b/kappa antibody (Complex)
Neuronal acetylcholine receptor subunit beta-4 (Complex)
Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
Neuronal acetylcholine receptor subunit alpha-3 (Complex)
Kappa fab light chain (Complex)
Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
Sodium ion (22 Da, Ligand)

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