EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Hibbs RE" AND author_orcid:"0000-0003-4390-8556" AND xref_links:"pdbekb" AND author_name:"Kim JJ" AND film_detector_model:"GATAN K2 SUMMIT (4K X 4K)" AND author_name:"Teng J" AND xref_links:"uniprot"

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EMD-22033

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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil

Release date: Sept. 9, 2020
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3u
Q-score: 0.462

Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE

Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]

Sample:

2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil (Complex)
Kappa fab light chain (23 kDa, Protein from Mus musculus)
Gamma-amino-butanoic acid (103 Da, Ligand)
Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Igg2b/kappa antibody (Complex from Mus musculus)
Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)

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