Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 6pv7
Q-score: 0.501
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Igg2b heavy chain (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (s)-3-(1-methylpyrrolidin-2-yl)pyridine (162 Da, Ligand)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Igg2b/kappa antibody (Complex)
- Nonane (128 Da, Ligand)
- Water (18 Da, Ligand)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to nicotine (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Kappa fab light chain (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6pv8
Q-score: 0.416
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Igg2b heavy chain (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to at-1001 (Complex from Homo sapiens)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- (3-endo)-n-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (309 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Kappa fab light chain (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)