The local refined map of Omicron spike with bispecific antibody FD01
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7wop
Q-score: 0.318
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 16l9 (25 kDa, Protein from Homo sapiens)
- Omicron spike with 16l9 and gw01 (Complex)
- Gw01 (26 kDa, Protein from Homo sapiens)
The state 1 of Omicron Spike with bispecific antibody FD01
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7woq
Q-score: 0.322
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omicron spike with 16l9 fv (Complex)
- 16l9 fv (Complex from Homo sapiens)
The state 2 of Omicron Spike with bispecific antibody FD01
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wor
Q-score: 0.236
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron spike with 16l9 and gw01 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Gw01 fv (26 kDa, Protein from Homo sapiens)
The state 3 of Omicron Spike with bispecific antibody FD01
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 7wos
Q-score: 0.235
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron spike with 16l9 and gw01 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Gw01 fv (26 kDa, Protein from Homo sapiens)
The state 4 of Omicron Spike with bispecific antibody FD01
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7wou
Q-score: 0.24
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- Omicron spike with 16l9 and gw01 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Gw01 fv (26 kDa, Protein from Homo sapiens)
The state 5 of Omicron Spike with bispecific antibody FD01
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7wov
Q-score: 0.185
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Omicron spike with 16l9 and gw01 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Gw01 fv (26 kDa, Protein from Homo sapiens)
The state 6 of Omicron Spike with bispecific antibody FD01
Resolution: 6.11 Å
EM Method: Single-particle
Fitted PDBs: 7wow
Q-score: 0.102
Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J
Cell Discov (2022) 8 pp. 104- [ Pubmed: 36207299 DOI: doi:10.1038/s41421-022-00463-6 ]
- 16l9 and gw01 (Complex from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 16l9 fv (25 kDa, Protein from Homo sapiens)
- Omicron spike with 16l9 and gw01 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Gw01 fv (26 kDa, Protein from Homo sapiens)
Omicron spike trimer with 6m6 antibody
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7wjy
Q-score: 0.31
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ Pubmed: 35768499 DOI: doi:10.1038/s41422-022-00684-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Omicron spike with 6m6 (Complex)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 6m6 (Complex from Homo sapiens)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Omicron Spike bitrimer with 6m6 antibody
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7wjz
Q-score: 0.288
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ Pubmed: 35768499 DOI: doi:10.1038/s41422-022-00684-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Omicron spike with 6m6 (Complex)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 6m6 (Complex from Homo sapiens)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Local refine of Omicron spike bitrimer with 6m6 antibody
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7wk0
Q-score: 0.431
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ Pubmed: 35768499 DOI: doi:10.1038/s41422-022-00684-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)
- Omicron spike with bn03 (Complex)
- Bn03 (Complex from Homo sapiens)