Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7jl0
Q-score: 0.395
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S
Mol Cell (2021) 81 pp. 599-613.e8 [ DOI: doi:10.1016/j.molcel.2020.11.047 Pubmed: 33373584 ]
- Interferon-induced helicase c domain-containing protein 1 (84 kDa, Protein from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Tripartite motif-containing protein 65 (21 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*cp*ap*gp*up*cp*ap*gp*up*cp*ap*gp*up*c)-3') (4 kDa, RNA from Homo sapiens)
- Ternary complex of mda5:dsrna:trim65 (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Rna (5'-r(p*gp*ap*cp*up*gp*ap*cp*up*gp*ap*cp*up*gp*a)-3') (4 kDa, RNA from Homo sapiens)
Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7jl1
Q-score: 0.489
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S
Mol Cell (2021) 81 pp. 599-613.e8 [ DOI: doi:10.1016/j.molcel.2020.11.047 Pubmed: 33373584 ]
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Ternary complex of rig-i:dsrna:riplet pryspry (Complex from Homo sapiens)
- Dsrna strand 2 (4 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- E3 ubiquitin-protein ligase rnf135 (21 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dsrna strand 1 (4 kDa, RNA from Homo sapiens)
- Antiviral innate immune response receptor rig-i (82 kDa, Protein from Homo sapiens)
Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer)
Resolution: 4.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 7jl2
Q-score: 0.362
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S
Mol Cell (2021) 81 pp. 599-613.e8 [ DOI: doi:10.1016/j.molcel.2020.11.047 Pubmed: 33373584 ]
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Rna (44-mer) (13 kDa, RNA from Homo sapiens)
- Tripartite motif-containing protein 65 (21 kDa, Protein from Homo sapiens)
- Rna (44-mer) (14 kDa, RNA from Homo sapiens)
- Interferon-induced helicase c domain-containing protein 1 (84 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ternary complex of mda5-dsrna-trim65 (Complex from Homo sapiens)
Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer)
Resolution: 4.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 7jl3
Q-score: 0.296
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S
Mol Cell (2021) 81 pp. 599-613.e8 [ DOI: doi:10.1016/j.molcel.2020.11.047 Pubmed: 33373584 ]
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Dsrna strand 2 (13 kDa, RNA from Homo sapiens)
- Dsrna strand1 (13 kDa, RNA from Homo sapiens)
- Antiviral innate immune response receptor rig-i (82 kDa, Protein from Homo sapiens)
- Ternary complex of dsrna-bound rig-i filament with riplet pryspry domain (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rnf135 (21 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)