Cryo-EM structure of NLRP3 open octamer
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8swf
Q-score: 0.31
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Cryo-EM structure of NLRP3 closed hexamer
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8swk
Q-score: 0.24
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Structure of NLRP3 and NEK7 complex
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8sxn
Q-score: 0.33
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- Covid spike variant deltan135 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Serine/threonine-protein kinase nek7 (34 kDa, Protein from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8fvu
Q-score: 0.412
Matico RE, Yu X, Miller R, Somani S, Ricketts MD, Kumar N, Steele RA, Medley Q, Berger S, Faustin B, Sharma S
Nat Struct Mol Biol (2024) 31 pp. 82-91 [ DOI: doi:10.1038/s41594-023-01143-z Pubmed: 38177670 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Burkholderia needle (chimeric with an anthrax toxin lethal factor tag) (Complex from Bacillus anthracis)
- Human naip and nlrc4 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Lethal factor,type iii secretion system protein (42 kDa, Protein from Burkholderia)
- Nlr family card domain-containing protein 4 (116 kDa, Protein from Homo sapiens)
- The complex of needle, human naip and nlrc4 (Complex)
- Baculoviral iap repeat-containing protein 1 (160 kDa, Protein from Homo sapiens)
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8fw2
Q-score: 0.331
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8fw9
Q-score: 0.24