TAF15 amyloid fold in atypical FTLD - Individual 1
Resolution: 1.97 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ons
Q-score: 0.749
Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B
Nature (2024) 625 pp. 345-351 [ DOI: doi:10.1038/s41586-023-06801-2 Pubmed: 38057661 ]
- Water (18 Da, Ligand)
- Taf15 atypical ftld amyloid fold (Tissue from Homo sapiens)
- Tata-binding protein-associated factor 2n (61 kDa, Protein from Homo sapiens)
Structure of apo telomeric nucleosome
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8ox0
Q-score: 0.607
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
Sci Adv (2023) 9 pp. eadi4148-eadi4148 [ DOI: doi:10.1126/sciadv.adi4148 Pubmed: 37624885 ]
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Trf1core in complex with telomeric nucleosome (Complex)
- Histone h2b type 1-c/e/f/g/i (14 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Human telomeric nucleosome (Complex from Homo sapiens)
- Telomeric dna g strand (46 kDa, DNA from Homo sapiens)
- Histone h2a type 1-c (14 kDa, Protein from Homo sapiens)
- Telomeric dna c strand (43 kDa, DNA from Homo sapiens)
Structure of TRF1core in complex with telomeric nucleosome
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ox1
Q-score: 0.579
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
Sci Adv (2023) 9 pp. eadi4148-eadi4148 [ DOI: doi:10.1126/sciadv.adi4148 Pubmed: 37624885 ]
- Telomeric repeat-binding factor 1 (50 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Trf1core in complex with telomeric nucleosome (Complex)
- Histone h2b type 1-c/e/f/g/i (14 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Human trf1core complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Human telomeric nucleosome (Complex from Homo sapiens)
- Telomeric dna g strand (46 kDa, DNA from Homo sapiens)
- Histone h2a type 1-c (14 kDa, Protein from Homo sapiens)
- Telomeric repeat-binding factor 1 (50 kDa, Protein from Homo sapiens)
- Telomeric dna c strand (43 kDa, DNA from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8bpo
Q-score: 0.549
Hopfler M, Absmeier E, Peak-Chew SY, Vartholomaiou E, Passmore LA, Gasic I, Hegde RS
Mol Cell (2023) 83 pp. 2290- [ Pubmed: 37295431 DOI: doi:10.1016/j.molcel.2023.05.020 ]
- 60s ribosomal protein l14 (23 kDa, Protein from rabbit)
- 60s ribosomal protein l23 (14 kDa, Protein from rabbit)
- 60s ribosomal protein l4 (47 kDa, Protein from rabbit)
- 60s ribosomal protein l6 (33 kDa, Protein from rabbit)
- Ubiquitin-60s ribosomal protein l40 (11 kDa, Protein from rabbit)
- S phase cyclin a-associated protein in the endoplasmic reticulum (159 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l39-like (6 kDa, Protein from rabbit)
- 60s ribosomal protein l37a (10 kDa, Protein from rabbit)
- 60s ribosomal protein l34 (13 kDa, Protein from rabbit)
- 60s ribosomal protein l36a-like (12 kDa, Protein from rabbit)
- 60s ribosomal protein l35a (12 kDa, Protein from rabbit)
- 5s ribosomal rna (38 kDa, RNA from rabbit)
- 60s ribosomal protein l36 (12 kDa, Protein from rabbit)
- 60s ribosomal protein l41 (3 kDa, Protein from rabbit)
- 60s ribosomal protein l17 (21 kDa, Protein from rabbit)
- Rabbit 80s ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (ttc5) and s-phase cyclin a associated protein residing in the er (scaper) (Complex from Oryctolagus cuniculus)
- Ribosomal protein l26 (17 kDa, Protein from rabbit)
- 60s ribosomal protein l19 (23 kDa, Protein from rabbit)
- 60s ribosomal protein l9 (21 kDa, Protein from rabbit)
- 60s ribosomal protein l31 (14 kDa, Protein from rabbit)
- Nascent polypeptide-associated complex subunit alpha n-terminal region (2 kDa, Protein from Oryctolagus cuniculus)
- Tubulin beta chain (7 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l22 (14 kDa, Protein from rabbit)
- 60s ribosomal protein l13a (23 kDa, Protein from rabbit)
- 60s ribosomal protein l8 (28 kDa, Protein from rabbit)
- 60s ribosomal protein l18a (20 kDa, Protein from rabbit)
- 60s ribosomal protein l27a (16 kDa, Protein from rabbit)
- Ribosomal protein l37 (11 kDa, Protein from rabbit)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l7 (29 kDa, Protein from rabbit)
- Ribosomal protein l24 (17 kDa, Protein from rabbit)
- Ribosomal protein l32 (15 kDa, Protein from rabbit)
- 60s ribosomal protein l7a (36 kDa, Protein from rabbit)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l29 (24 kDa, Protein from rabbit)
- Ribosomal_l18_c domain-containing protein (34 kDa, Protein from rabbit)
- 60s ribosomal protein l30 (12 kDa, Protein from rabbit)
- 28s ribosomal rna (1 MDa, RNA from Oryctolagus cuniculus)
- 60s ribosomal protein l38 (8 kDa, Protein from rabbit)
- Ribosomal protein l15 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l21 (18 kDa, Protein from rabbit)
- Tetratricopeptide repeat protein 5 (54 kDa, Protein from Homo sapiens)
- Ribosomal protein l10 (24 kDa, Protein from rabbit)
- Ribosomal protein l18 (21 kDa, Protein from rabbit)
- 60s ribosomal protein l13 (24 kDa, Protein from rabbit)
- 60s ribosomal protein l12 (17 kDa, Protein from rabbit)
- Ribosomal_l23en domain-containing protein (17 kDa, Protein from rabbit)
- 60s ribosomal protein l28 (15 kDa, Protein from rabbit)
- 5.8s ribosomal rna (50 kDa, RNA from rabbit)
- 60s ribosomal protein l11 (20 kDa, Protein from rabbit)
- 60s acidic ribosomal protein p0 (34 kDa, Protein from rabbit)
- Ribosomal protein l3 (46 kDa, Protein from rabbit)
- 60s ribosomal protein l35 (14 kDa, Protein from rabbit)
- 60s ribosomal protein l27 (15 kDa, Protein from rabbit)
Resolution: 1.99 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bg0
Q-score: 0.743
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ Pubmed: 36611124 DOI: doi:10.1007/s00401-022-02533-1 ]
Type I beta-amyloid 42 Filaments from Human Brain
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4b
Q-score: 0.688
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ DOI: doi:10.1126/science.abm7285 Pubmed: 35025654 ]
- Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)
- Amyloid-beta precursor protein (4 kDa, Protein from Human)
- Unknown atom or ion (Ligand)
- Water (18 Da, Ligand)