Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Peak-Chew SY" AND xref_links:"pdb" AND author_orcid:"0000-0003-2238-6437" AND author_name:"Goedert M"

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EMD-13800

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Type I beta-amyloid 42 Filaments from Human Brain

Release date: Nov. 24, 2021
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4b
Q-score: 0.688

Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M

Science (2022) 375 pp. 167-172 [ DOI: doi:10.1126/science.abm7285 Pubmed: 35025654 ]

Sample:

Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)
Amyloid-beta precursor protein (4 kDa, Protein from Human)
Unknown atom or ion (Ligand)
Water (18 Da, Ligand)

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EMD-13809

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Type II beta-amyloid 42 Filaments from Human Brain

Release date: Nov. 24, 2021
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4m
Q-score: 0.631

Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M

Science (2022) 375 pp. 167-172 [ DOI: doi:10.1126/science.abm7285 Pubmed: 35025654 ]

Sample:

Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)
Amyloid-beta precursor protein (4 kDa, Protein from Human)
Unknown atom or ion (Ligand)

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EMDB [2]

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