Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
Resolution: 2.42 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pic
Q-score: 0.647
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH.
Resolution: 3.41 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pix
Q-score: 0.532
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Resolution: 2.31 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pjo
Q-score: 0.672
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM structure of the type 1m polymorph of alpha-synuclein
Resolution: 3.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pk2
Q-score: 0.542
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 5A polymorph of alpha-synuclein.
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pk4
Q-score: 0.541
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM map of the type 2A polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
Cryo EM map of the type 2B polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]