Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
Resolution: 2.42 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pic
Q-score: 0.647
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH.
Resolution: 3.41 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pix
Q-score: 0.532
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Resolution: 2.31 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pjo
Q-score: 0.672
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM structure of the type 1m polymorph of alpha-synuclein
Resolution: 3.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pk2
Q-score: 0.542
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 5A polymorph of alpha-synuclein.
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pk4
Q-score: 0.541
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM map of the type 2A polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
Cryo EM map of the type 2B polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Böckmann A, Bousset L, Stahlberg H
Elife (2019) 8 [ Pubmed: 31815671 DOI: 10.7554/eLife.48907 ]
Image sets:
cryo-em structure of alpha-synuclein fibril polymorph 2B
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 6sst
Q-score: 0.511
Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Bockmann A, Bousset L, Stahlberg H
eLife (2019) 8 [ Pubmed: 31815671 DOI: doi:10.7554/eLife.48907 ]
- Alpha synuclein fibril, polymorph 2b (51 MDa, Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
cryo-em structure of alpha-synuclein fibril polymorph 2A
Resolution: 2.98 Å
EM Method: Helical reconstruction
Fitted PDBs: 6ssx
Q-score: 0.551
Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Bockmann A, Bousset L, Stahlberg H
eLife (2019) 8 [ Pubmed: 31815671 DOI: doi:10.7554/eLife.48907 ]
- Alpha synuclein fibril, polymorph 2a (51 MDa, Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)