BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels T, Ozorowski G, Ward AB, Sanders RW
To Be Published
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Siddaramaiah LK, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner HL, Rubin V, Furth S, MacPhee K, Duff M, Corey L, Keefer MC, Edupuganti S, Frank I, Maenza J, Baden LR, Hyrien O, Sanders RW, Moore JP, Ward AB, Tomaras GD, Montefiori DC, Rouphael N, McElrath MJ
medRxiv (2024) [ Pubmed: 38766048 DOI: doi:10.1101/2024.05.08.24306957 ]
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Siddaramaiah LK, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner HL, Rubin V, Furth S, MacPhee K, Duff M, Corey L, Keefer MC, Edupuganti S, Frank I, Maenza J, Baden LR, Hyrien O, Sanders RW, Moore JP, Ward AB, Tomaras GD, Montefiori DC, Rouphael N, McElrath MJ
medRxiv (2024) [ Pubmed: 38766048 DOI: doi:10.1101/2024.05.08.24306957 ]
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Siddaramaiah LK, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner HL, Rubin V, Furth S, MacPhee K, Duff M, Corey L, Keefer MC, Edupuganti S, Frank I, Maenza J, Baden LR, Hyrien O, Sanders RW, Moore JP, Ward AB, Tomaras GD, Montefiori DC, Rouphael N, McElrath MJ
medRxiv (2024) [ Pubmed: 38766048 DOI: doi:10.1101/2024.05.08.24306957 ]
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Siddaramaiah LK, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner HL, Rubin V, Furth S, MacPhee K, Duff M, Corey L, Keefer MC, Edupuganti S, Frank I, Maenza J, Baden LR, Hyrien O, Sanders RW, Moore JP, Ward AB, Tomaras GD, Montefiori DC, Rouphael N, McElrath MJ
medRxiv (2024) [ Pubmed: 38766048 DOI: doi:10.1101/2024.05.08.24306957 ]
Hahn WO, Parks KR, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Woodward Davis AS, Duplessis C, Tomai M, Dey AK, Sagawa ZK, De Rosa SC, Seese A, Siddaramaiah LK, Stamatatos L, Lee WH, Sewall LM, Karlinsey D, Turner HL, Rubin V, Furth S, MacPhee K, Duff M, Corey L, Keefer MC, Edupuganti S, Frank I, Maenza J, Baden LR, Hyrien O, Sanders RW, Moore JP, Ward AB, Tomaras GD, Montefiori DC, Rouphael N, McElrath MJ
medRxiv (2024) [ Pubmed: 38766048 DOI: doi:10.1101/2024.05.08.24306957 ]
chEnv TTT protein in complex with 43A2 Fab
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ Pubmed: 38582771 DOI: doi:10.1038/s41541-024-00862-8 ]
chEnv TTT protein in complex with CM01A Fab
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ DOI: doi:10.1038/s41541-024-00862-8 Pubmed: 38582771 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ Pubmed: 38582771 DOI: doi:10.1038/s41541-024-00862-8 ]
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines (cH125 TTT)
Del Moral-Sanchez I, Wee EG, Xian Y, Lee WH, Allen JD, Torrents de la Pena A, Froes Rocha R, Ferguson J, Leon AN, Koekkoek S, Schermer EE, Burger JA, Kumar S, Zwolsman R, Brinkkemper M, Aartse A, Eggink D, Han J, Yuan M, Crispin M, Ozorowski G, Ward AB, Wilson IA, Hanke T, Sliepen K, Sanders RW
NPJ Vaccines (2024) 9 pp. 74-74 [ Pubmed: 38582771 DOI: doi:10.1038/s41541-024-00862-8 ]