Cryo-EM structure of CD38 in complex with FTL004
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 8il3
Q-score: 0.387
Zhang G, Guo C, Wang Y, Zhang X, Liu S, Qu W, Chen C, Yan L, Yang Z, Zhang Z, Jiang X, Chen X, Liu H, Lai Q, Wei X, Lu Y, Zhao S, Deng H, Wang Y, Yu L, Yu H, Wu Y, Su Z, Chen P, Ren Z, Yu M, Qu F, Luo Y, Gou L, Li Q, Huang Y, Ma F, Yang J
J Hematol Oncol (2022) 15 pp. 177-177 [ Pubmed: 36581954 DOI: doi:10.1186/s13045-022-01395-0 ]
- Heavy chain (22 kDa, Protein from Homo sapiens)
- Adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of cd38 in complex with ftl004 (Complex from Homo sapiens)
- Light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a eukaryotic ZnT8 in the presence of zinc
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7y5g
Q-score: 0.438
Zhang S, Fu C, Luo Y, Xie Q, Xu T, Sun Z, Su Z, Zhou X
J Struct Biol (2022) 215 pp. 107926-107926 [ DOI: doi:10.1016/j.jsb.2022.107926 Pubmed: 36464198 ]
- Xtznt8 dimer complexed with zinc (Complex from Xenopus tropicalis)
- Zinc ion (65 Da, Ligand)
- Zinc transporter 8 (41 kDa, Protein from Xenopus tropicalis)
Cryo-EM structure of a eukaryotic ZnT8 at a low pH
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7y5h
Q-score: 0.442
Zhang S, Fu C, Luo Y, Xie Q, Xu T, Sun Z, Su Z, Zhou X
J Struct Biol (2022) 215 pp. 107926-107926 [ DOI: doi:10.1016/j.jsb.2022.107926 Pubmed: 36464198 ]
- Xtznt8 dimer complexed with zinc and proton (Complex from Xenopus tropicalis)
- Zinc ion (65 Da, Ligand)
- Zinc transporter 8 (41 kDa, Protein from Xenopus tropicalis)
Cryo-EM of the OmcE nanowires from Geobacter sulfurreducens
Resolution: 4.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 7tfs
Q-score: 0.343
Wang F, Mustafa K, Suciu V, Joshi K, Chan CH, Choi S, Su Z, Si D, Hochbaum AI, Egelman EH, Bond DR
Nat Microbiol (2022) 7 pp. 1291-1300 [ Pubmed: 35798889 DOI: doi:10.1038/s41564-022-01159-z ]
- Filament of omce protein (Complex from Geobacter sulfurreducens)
- Cytochrome c (23 kDa, Protein from Geobacter sulfurreducens)
- Heme c (618 Da, Ligand)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 7wld
Q-score: 0.615
Xu Y, Jia G, Li T, Zhou Z, Luo Y, Chao Y, Bao J, Su Z, Qu Q, Li D
Nat Commun (2022) 13 pp. 2617-2617 [ DOI: doi:10.1038/s41467-022-30250-6 Pubmed: 35551457 ]
- Gpi transamidase component pig-t (94 kDa, Protein from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[[(1~{s},2~{r},3~{r},4~{s},5~{s},6~{r})-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-propan-2-yl] (9~{z},11~{z})-octadeca-9,11-dienoate (1 kDa, Ligand)
- Cardiolipin (1 kDa, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate (720 Da, Ligand)
- 2-azanylethyl [(2~{s},3~{s},4~{s},5~{s},6~{r})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate (303 Da, Ligand)
- (4s,7r)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-n,n,n-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminium (763 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Gpi transamidase complex (Complex from Homo sapiens)
- Gpi-anchor transamidase (73 kDa, Protein from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Glycosylphosphatidylinositol anchor attachment 1 protein (96 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Gpi transamidase component pig-s (90 kDa, Protein from Homo sapiens)
- 2-amino-2-deoxy-alpha-d-glucopyranose (179 Da, Ligand)
- Phosphatidylinositol glycan anchor biosynthesis class u protein (80 kDa, Protein from Homo sapiens)
Cryo-EM structure of PilA-N and PilA-C from Geobacter sulfurreducens
Resolution: 4.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 7tgg
Q-score: 0.364
Wang F, Mustafa K, Suciu V, Joshi K, Chan CH, Choi S, Su Z, Si D, Hochbaum AI, Egelman EH, Bond DR
Nat Microbiol (2022) 7 pp. 1291-1300 [ Pubmed: 35798889 DOI: doi:10.1038/s41564-022-01159-z ]
Structure of the translating Neurospora crassa ribosome arrested by cycloheximide
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7r81
Q-score: 0.539
Shen L, Su Z, Yang K, Wu C, Becker T, Bell-Pedersen D, Zhang J, Sachs MS
PNAS (2021) 118 [ Pubmed: 34815343 DOI: doi:10.1073/pnas.2111862118 ]
- 60s ribosomal protein l15 (24 kDa, Protein from Neurospora crassa)
- 18s rrna (578 kDa, RNA from Neurospora crassa)
- Ribosomal protein l19 (22 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s16 (15 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l38 (9 kDa, Protein from Neurospora crassa)
- Ribosomal protein srp1 (18 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l36 (11 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s23 (15 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s12 (16 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l22 (14 kDa, Protein from Neurospora crassa)
- Structure of the translating neurospora crassa ribosome arrested by cycloheximide (Complex)
- 40s ribosomal protein s7 (22 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l28 (16 kDa, Protein from Neurospora crassa)
- Hypothetical protein ncu16635 (el41) (3 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l9 (21 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s2 (28 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l7 (28 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein (14 kDa, Protein from Neurospora crassa)
- Mrna (Complex from Neurospora crassa)
- 60s ribosomal protein l20 (20 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s17 (16 kDa, Protein from Neurospora crassa)
- Ribosomal protein l26 (15 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l30 (11 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s14 (us11) (16 kDa, Protein from Neurospora crassa)
- Nascent peptide (Complex from Neurospora crassa)
- 40s ribosomal subunit (Complex from Neurospora crassa)
- 5.8s rrna (50 kDa, RNA from Neurospora crassa)
- 60s ribosomal protein l40 (6 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l32 (15 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s6 (27 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l6 (22 kDa, Protein from Neurospora crassa)
- Guanine nucleotide-binding protein subunit beta-like protein (35 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s21 (9 kDa, Protein from Neurospora crassa)
- Ribosomal_l28e domain-containing protein (16 kDa, Protein from Neurospora crassa)
- 4-{(2r)-2-[(1s,3s,5s)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione (281 Da, Ligand)
- 60s ribosomal protein l8 (29 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s9 (21 kDa, Protein from Neurospora crassa)
- Spermidine (145 Da, Ligand)
- 60s ribosomal protein l24 (17 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s26e (13 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s25 (10 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s13 (16 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s24 (15 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l33 (12 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l35 (14 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s30 (6 kDa, Protein from Neurospora crassa)
- Ribosomal protein s12 (17 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l17 (20 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l4-a (38 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s11 (18 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s1 (29 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l34 (13 kDa, Protein from Neurospora crassa)
- 26s rrna (1 MDa, RNA from Neurospora crassa)
- Ribosomal protein l37 (10 kDa, Protein from Neurospora crassa)
- Mrna (5 kDa, RNA from Neurospora crassa)
- 60s ribosomal protein l43 (10 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l2 (27 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l5 (34 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s4 (29 kDa, Protein from Neurospora crassa)
- Trna (24 kDa, RNA from Neurospora crassa)
- Trna (Complex from Neurospora crassa)
- 60s ribosomal protein l23 (14 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l11 (20 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s29 (6 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s20 (13 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l3 (44 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s5 (23 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l29 (7 kDa, Protein from Neurospora crassa)
- Ribosomal protein l14 (15 kDa, Protein from Neurospora crassa)
- 60s ribosomal subunit (Complex from Neurospora crassa)
- 40s ribosomal protein s0 (31 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l39 (6 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l27 (el27) (15 kDa, Protein from Neurospora crassa)
- Ubiquitin-40s ribosomal protein s27a (17 kDa, Protein from Neurospora crassa)
- 5s rrna (38 kDa, RNA from Neurospora crassa)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l13 (23 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l25 (17 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s18 (17 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l16 (26 kDa, Protein from Neurospora crassa)
- Nascent peptide (358 Da, Protein from Neurospora crassa)
- 40s ribosomal protein s27 (8 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l18 (20 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s22 (14 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s19 (16 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l44 (11 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s28 (7 kDa, Protein from Neurospora crassa)
- 60s ribosomal protein l10 (25 kDa, Protein from Neurospora crassa)
- 40s ribosomal protein s8 (23 kDa, Protein from Neurospora crassa)
- Cytoplasmic ribosomal protein 10 (28 kDa, Protein from Neurospora crassa)
- Probable 40s ribosomal protein s10-b (18 kDa, Protein from Neurospora crassa)
Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7evy
Q-score: 0.494
Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z
Cell Res (2021) 31 pp. 1263-1274 [ Pubmed: 34526663 DOI: doi:10.1038/s41422-021-00566-x ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 1-[[4-[(~{e})-~{n}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{c}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid (516 Da, Ligand)
- Sphingosine 1-phosphate receptor 1 (60 kDa, Protein from Homo sapiens)
- Sphingosine-1-phosphate receptor 1 complexed with gi protein with bound siponimod (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of cenerimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 7evz
Q-score: 0.493
Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z
Cell Res (2021) 31 pp. 1263-1274 [ Pubmed: 34526663 DOI: doi:10.1038/s41422-021-00566-x ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Sphingosine 1-phosphate receptor 1 (60 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- (2~{s})-3-[4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy]propane-1,2-diol (453 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Sphingosine-1-phosphate receptor 1 complexed with gi protein with bound cenerimod (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7ew0
Q-score: 0.461
Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z
Cell Res (2021) 31 pp. 1263-1274 [ Pubmed: 34526663 DOI: doi:10.1038/s41422-021-00566-x ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 5-[3-[(1~{s})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{h}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile (404 Da, Ligand)
- Sphingosine 1-phosphate receptor 1 (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Sphingosine-1-phosphate receptor 1 complexed with gi protein with bound ozanimod (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)