PKA-phosphorylated human ryanodine receptor type 2 in the presence of calmodulin - RyR2 + CaM
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
PKA-phosphorylated CPVT variant human ryanodine receptor type 2 R2474S - RyR2-R2474S
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
dephosphorylated human ryanodine receptor type 2 RyR2
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
PKA-phosphorylated human ryanodine receptor type 2 RyR2
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 [ DOI: 10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Image sets:
Structure of human RyR2 in the closed state.
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Structure of PKA phosphorylated human RyR2 in the closed state
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7u9q
Q-score: 0.377
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Complex of ryr2 and calstabin-2 (Complex)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
Structure of PKA phosphorylated human RyR2 in the open state
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7u9r
Q-score: 0.353
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Xanthine (152 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complex of ryr2 and calstabin-2 (Complex)
Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 7u9t
Q-score: 0.427
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of ryr2, calstabin-2, and calmodulin (Complex)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)