Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
Cryo-EM structure of endothelin1-bound ETAR-Gq complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hcq
Q-score: 0.394
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Endothelin-1 receptor,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
Cryo-EM structure of Endothelin1-bound ETBR-Gq complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hcx
Q-score: 0.346
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ Pubmed: 36543774 DOI: doi:10.1038/s41421-022-00499-8 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ DOI: doi:10.1038/s41422-022-00751-6 Pubmed: 36588120 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Acth (Complex from Homo sapiens)
- Corticotropin (2 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Melanocortin-2 receptor (Complex from Homo sapiens)
- Mrap1 (Complex from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w53
Q-score: 0.514
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- The neuromedin u-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 1 (83 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7w55
Q-score: 0.489
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- The neuromedin u-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w56
Q-score: 0.477
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Neuromedin u receptor 1 (83 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w57
Q-score: 0.533
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cz5
Q-score: 0.582
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2020) 11 pp. 5205-5205 [ Pubmed: 33060564 DOI: doi:10.1038/s41467-020-18945-0 ]
- Hormone receptor, g(s) subunit alpha isoforms (Complex from Homo sapiens)
- Nanobody35 (13 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Hormone (Complex from Homo sapiens)
- G(s) subunit beta-1 (Complex from Rattus norvegicus)
- Growth hormone-releasing hormone receptor - gs protein complex (180 kDa, Complex)
- Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor (61 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Somatoliberin (5 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Nanobody35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- G(s) subunit gamma-2 (Complex from Bos taurus)