Cryo-EM Structure of CdnG-E2 complex from Serratia marcescens (UltrAuFoil)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hsb
Q-score: 0.38
Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
Nat Microbiol (2024) 9 pp. 1566-1578 [ Pubmed: 38649411 DOI: doi:10.1038/s41564-024-01684-z ]
- Type vi secretion protein (18 kDa, Protein from Serratia marcescens)
- Cdng-e2 binary complex (Complex from Serratia marcescens)
- Cdng (45 kDa, Protein from Serratia marcescens)
Cryo-EM Structure of CdnG-E2 complex from Serratia marcescens
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8yjy
Q-score: 0.426
Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
Nat Microbiol (2024) 9 pp. 1566-1578 [ Pubmed: 38649411 DOI: doi:10.1038/s41564-024-01684-z ]
- Cdng-e2 binary complex (Complex from Serratia marcescens)
- Type vi secretion protein (18 kDa, Protein from Serratia marcescens)
- Smcdng (45 kDa, Protein from Serratia marcescens)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9a
Q-score: 0.591
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]
- Human pi3k-alpha (p85/p110-h1047r) with qr-7909 binding at an allosteric site (Complex from Homo sapiens)
- 6-chloranyl-3-[[(1r)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid (490 Da, Ligand)
- Water (18 Da, Ligand)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w9b
Q-score: 0.496
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]
- Phosphatidylinositol 3-kinase regulatory subunit alpha (33 kDa, Protein from Homo sapiens)
- Human pi3k-alpha (p85/p110-h1047r) with qr-8557 binding at an allosteric site (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- 1-[(1s)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea (395 Da, Ligand)
Cryo-EM structure of human HCN3 channel in apo state
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8inz
Q-score: 0.526
Yu B, Lu Q, Li J, Cheng X, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y, Fu Y, Zhang J
J Biol Chem (2024) 300 pp. 107288-107288 [ Pubmed: 38636662 DOI: doi:10.1016/j.jbc.2024.107288 ]
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (86 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Complex from Homo sapiens)
- 4-[[(2~{s},4~{a}~{r},6~{s},8~{a}~{s})-6-[(4~{s},5~{r})-4-[(2~{s})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{h}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid (492 Da, Ligand)
Cryo-EM structure of human HCN3 channel with cilobradine
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8io3
Q-score: 0.486
To Be Published
- Otassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Complex from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (86 kDa, Protein from Homo sapiens)
- 3-[[(3~{s})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{h}-3-benzazepin-4-one (482 Da, Ligand)
Cellular components in INS-1E cell periphery
Li W, Li A, Yu B, Zhang X, Liu X, White KL, Stevens RC, Baumeister W, Sali A, Jasnin M, Sun L
Nat Commun (2024) 15 pp. 1311-1311 [ DOI: doi:10.1038/s41467-024-45648-7 Pubmed: 38346988 ]
- Ins-1e cell (Cell from Rattus)
Li W, Li A, Yu B, Zhang X, Liu X, White KL, Stevens RC, Baumeister W, Sali A, Jasnin M, Sun L
Nat Commun (2024) 15 pp. 1311-1311 [ DOI: doi:10.1038/s41467-024-45648-7 Pubmed: 38346988 ]
- Ins-1e cell (Cell from Rattus)
Li W, Li A, Yu B, Zhang X, Liu X, White KL, Stevens RC, Baumeister W, Sali A, Jasnin M, Sun L
Nat Commun (2024) 15 pp. 1311-1311 [ Pubmed: 38346988 DOI: doi:10.1038/s41467-024-45648-7 ]
- Ins-1e cell (Cell from Rattus)
Cellular components at INS-1E cell periphery under basal condition
Li W, Li A, Yu B, Zhang X, Liu X, White KL, Stevens RC, Baumeister W, Sali A, Jasnin M, Sun L
Nat Commun (2024) 15 pp. 1311-1311 [ DOI: doi:10.1038/s41467-024-45648-7 Pubmed: 38346988 ]
- Ins-1e cell (Cell from Rattus)