EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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dna/ polymerase AND electron_source:"FIELD EMISSION GUN" AND xref_links:"interpro" AND film_detector_model:"GATAN K3 (6K X 4K)" AND author_name:"Yan X"

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EMD-31811

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catalytic core of human telomerase holoenzyme

Release date: March 30, 2022
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7v99
Q-score: 0.247

Wan F, Ding Y, Zhang Y, Wu Z, Li S, Yang L, Yan X, Lan P, Li G, Wu J, Lei M

Cell Res (2021) 31 pp. 1275-1290 [ Pubmed: 34782750 DOI: doi:10.1038/s41422-021-00586-7 ]

Sample:

Primer dna (7 kDa, DNA from Homo sapiens)
Histone h2a type 1-b/e (14 kDa, Protein from Human)
Histone h2b type 1-k (13 kDa, Protein from Human)
Catalytic core (Complex from Homo sapiens)
Telomerase rna component (145 kDa, RNA from Human)
Telomerase reverse transcriptase (127 kDa, Protein from Human)

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EMD-31061

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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Release date: Feb. 16, 2022
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7ed5
Q-score: 0.522

Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B

Nat Commun (2022) 13 pp. 621-621 [ DOI: doi:10.1038/s41467-022-28113-1 Pubmed: 35110538 ]

Sample:

Nsp12-nsp7-nsp8 (Complex from Severe acute respiratory syndrome coronavirus 2)
[[(2r,3r,4r,5r)-5-(2-azanyl-6-oxidanylidene-1h-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (539 Da, Ligand)
Nsp12-nsp7-nsp8-rna-at9010 (160 kDa, Complex)
Rna-directed rna polymerase (109 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Non-structural protein 7 (12 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Rna (Complex)
Magnesium ion (24 Da, Ligand)
Zinc ion (65 Da, Ligand)
Rna (5'-r(p*cp*cp*cp*cp*ap*up*ap*ap*cp*up*up*ap*ap*up*cp*up*cp*ap*cp*ap*up*ap*gp*c)-3') (9 kDa, RNA from synthetic construct)
Non-structural protein 8 (24 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Rna (5'-r(p*gp*cp*up*ap*up*gp*up*gp*ap*gp*ap*up*up*ap*ap*gp*up*up*ap*u*(at9))-3') (6 kDa, RNA from synthetic construct)

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