Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 7mxp
Q-score: 0.192
Madan B, Reddem ER, Wang P, Casner RG, Nair MS, Huang Y, Fahad AS, de Souza MO, Banach BB, Lopez Acevedo SN, Pan X, Nimrania R, Teng IT, Bahna F, Zhou T, Zhang B, Yin MT, Ho DD, Kwong PD, Shapiro L, DeKosky BJ
Aiche J (2021) 67 pp. e17440-e17440 [ DOI: doi:10.1002/aic.17440 Pubmed: 34898670 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lp5 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Lp5 fab light chain (11 kDa, Protein from Homo sapiens)
- Lp5 heavy chain, lp5 light chain (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with lp5 fab (Complex)
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7n5h
Q-score: 0.321
Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD
Emerg Microbes Infect (2022) 11 pp. 147-157 [ Pubmed: 34836485 DOI: doi:10.1080/22221751.2021.2011623 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Broadly neutralizing antibody 2-36 in complex with prefusion sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-36 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-36 fab light chain (11 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7rw2
Q-score: 0.386
Cerutti G, Guo Y, Wang P, Nair MS, Wang M, Huang Y, Yu J, Liu L, Katsamba PS, Bahna F, Reddem ER, Kwong PD, Ho DD, Sheng Z, Shapiro L
Cell Rep (2021) 37 pp. 109928-109928 [ DOI: doi:10.1016/j.celrep.2021.109928 Pubmed: 34706271 ]
- 5-7 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 5-7 light chain (23 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-7 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7l56
Q-score: 0.475
Rapp M, Guo Y, Reddem ER, Yu J, Liu L, Wang P, Cerutti G, Katsamba P, Bimela JS, Bahna FA, Mannepalli SM, Zhang B, Kwong PD, Huang Y, Ho DD, Shapiro L, Sheng Z
Cell Rep (2021) 35 pp. 108950-108950 [ Pubmed: 33794145 DOI: doi:10.1016/j.celrep.2021.108950 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of the sars-cov-2 spike glycoprotein bound to fab 2-43 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab 2-43 variable domain heavy chain (14 kDa, Protein from Homo sapiens)
- Fab 2-43 variable domain light chain (11 kDa, Protein from Homo sapiens)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7l2e
Q-score: 0.505
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-18 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 4-18 fab (Complex from Homo sapiens)
- 4-18 heavy chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l2f
Q-score: 0.332
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-24 fab (Complex from Homo sapiens)
- 5-24 heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 5-24 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7ls9
Q-score: 0.429
Cerutti G, Rapp M, Guo Y, Bahna F, Bimela J, Reddem ER, Yu J, Wang P, Liu L, Huang Y, Ho DD, Kwong PD, Sheng Z, Shapiro L
Structure (2021) 29 pp. 655-663.e4 [ DOI: doi:10.1016/j.str.2021.05.014 Pubmed: 34111408 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 1-57 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 1-57 fab light chain (23 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with 1-57 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 6xey
Q-score: 0.454
Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD
Nature (2020) 584 pp. 450-456 [ Pubmed: 32698192 DOI: doi:10.1038/s41586-020-2571-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike glycoprotein bound to fab 2-4 (515 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-4 light chain (11 kDa, Protein from Homo sapiens)
- 2-4 heavy chain (13 kDa, Protein from Homo sapiens)