Electron Microscopy Data Bank

EMD-26864

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Tetrahymena telomerase with CST-PolaPrim

Release date: July 13, 2022
Resolution: 4.4 Å
EM Method: Single-particle

He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J

Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]

Sample:

EMD-26865

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Tetrahymena telomerase at 2.9 Angstrom resolution

Release date: July 13, 2022
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7uy6
Q-score: 0.506

He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J

Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]

Sample:

Tetrahymena telomerase holoenzyme (Complex from Tetrahymena thermophila)
Telomerase holoenzyme teb3 subunit (14 kDa, Protein from Tetrahymena thermophila)
Telomere dna (19 kDa, DNA from Tetrahymena thermophila)
Telomerase rna (50 kDa, RNA from Tetrahymena thermophila)
Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
Telomerase holoenzyme teb2 subunit (30 kDa, Protein from Tetrahymena thermophila)
Telomerase reverse transcriptase (133 kDa, Protein from Tetrahymena thermophila)
Telomerase la-related protein p65 (64 kDa, Protein from Tetrahymena thermophila)
Zinc ion (65 Da, Ligand)
Telomerase holoenzyme teb1 subunit (82 kDa, Protein from Tetrahymena thermophila)

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EMD-26866

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Tetrahymena CST with Polymerase alpha-Primase

Release date: July 13, 2022
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7uy7
Q-score: 0.293

He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J

Nature (2022) 608 pp. 813-818 [ DOI: doi:10.1038/s41586-022-04931-7 Pubmed: 35831498 ]

Sample:

Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
Tetrahymena cst (Complex from Tetrahymena thermophila)
Telomere dna (19 kDa, DNA from Tetrahymena thermophila)
Tetrahymena cst-polaprim (Complex)
Telomerase-associated protein of 45 kda (43 kDa, Protein from Tetrahymena thermophila)
Zinc ion (65 Da, Ligand)
Dna polymerase (161 kDa, Protein from Tetrahymena thermophila)
Telomerase-associated protein of 75 kda (73 kDa, Protein from Tetrahymena thermophila)
Tetrahymena dna polymerase alpha-primase (Complex from Tetrahymena thermophila)
Telomerase-associated protein of 19 kda (19 kDa, Protein from Tetrahymena thermophila)

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EMD-26867

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Tetrahymena Polymerase alpha-Primase

Release date: July 13, 2022
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7uy8
Q-score: 0.229

He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J

Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]

Sample:

Dna polymerase alpha subunit b (68 kDa, Protein from Tetrahymena thermophila)
Dna polymerase (161 kDa, Protein from Tetrahymena thermophila)
Dna primase (47 kDa, Protein from Tetrahymena thermophila)
Tetrahymena polaprim (Complex from Tetrahymena thermophila)
Eukaryotic-type dna primase, large subunit (64 kDa, Protein from Tetrahymena thermophila)
Zinc ion (65 Da, Ligand)

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EMD-26869

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Tetrahymena Polymerase alpha-Primase subunits PRIM2-PRIM1

Release date: July 13, 2022
Resolution: 4.3 Å
EM Method: Single-particle

He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J

Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]

Sample:

Tetrahymena polymerase alpha-primase (Complex from Tetrahymena thermophila)

EMD-26090

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Human telomerase catalytic core with TPP1-OB, P2a state1-1

Release date: May 4, 2022
Resolution: 4.2 Å
EM Method: Single-particle

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J

Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]

Sample:

Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)

EMD-26091

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Human telomerase catalytic core with TPP1-OB, P2a state 1-2

Release date: May 4, 2022
Resolution: 4.1 Å
EM Method: Single-particle

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J

Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]

Sample:

Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)

EMD-26092

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Human telomerase catalytic core with TPP1-OB, P2a state1-3

Release date: May 4, 2022
Resolution: 4.1 Å
EM Method: Single-particle

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J

Nature (2022) 604 pp. 578-583 [ DOI: doi:10.1038/s41586-022-04582-8 Pubmed: 35418675 ]

Sample:

Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)

EMD-26093

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Human telomerase catalytic core with TPP1-OB, P2a state2

Release date: May 4, 2022
Resolution: 4.0 Å
EM Method: Single-particle

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J

Nature (2022) 604 pp. 578-583 [ DOI: doi:10.1038/s41586-022-04582-8 Pubmed: 35418675 ]

Sample:

Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)

EMD-26094

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Human telomerase catalytic core without TPP1-OB, P2a state1

Release date: May 4, 2022
Resolution: 4.3 Å
EM Method: Single-particle

Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J

Nature (2022) 604 pp. 578-583 [ DOI: doi:10.1038/s41586-022-04582-8 Pubmed: 35418675 ]

Sample:

Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)

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