EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND assembly_molecular_weight:{100000 TO 250000] AND author_orcid:"0000-0001-8902-2473" AND author_orcid:"0000-0001-6406-8993" AND author_name:"Wang J" AND author_name:"Wootten D" AND author_name:"Sexton PM" AND author_orcid:"0000-0002-0622-609x"

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EMD-23280

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Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand

Release date: Sept. 8, 2021
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ld3
Q-score: 0.518

Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A

Nature (2021) 597 pp. 571-576 [ DOI: doi:10.1038/s41586-021-03897-2 Pubmed: 34497422 ]

Sample:

{2-amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone (449 Da, Ligand)
Human adenosine a1 receptor-gi2-protein complex bound to its endogenous agonist adenosine (Complex from Homo sapiens)
Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
Adenosine (267 Da, Ligand)
Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Water (18 Da, Ligand)
Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Chimera protein of muscarinic acetylcholine receptor m4 and adenosine receptor a1 (43 kDa, Protein from Homo sapiens)

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