Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9asj
Q-score: 0.411
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ Pubmed: 38895274 DOI: doi:10.1101/2024.06.07.597860 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Human dna polymerase theta helicase domain in complex with inhibitor amp-pnp (199 kDa, Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain dimer, apo-form
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9ask
Q-score: 0.389
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ Pubmed: 38895274 DOI: doi:10.1101/2024.06.07.597860 ]
- Human dna polymerase theta helicase domain dimer, apo-form (199 kDa, Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8qu8
Q-score: 0.306
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost A, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber A, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A
bioRxiv (2023) [ DOI: doi:10.1101/2023.10.24.563163 ]
- Cullin-2 (86 kDa, Protein from Homo sapiens)
- Kras/acbi3/vhl/elob/eloc/cul2/rbx1 (168 kDa, Complex from Homo sapiens)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (24 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- (2s,4r)-1-[(2s)-2-[4-[4-[(3s)-4-[4-[5-[(4s)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5h-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-n-[(1r)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide (1 kDa, Ligand)
- Zinc ion (65 Da, Ligand)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Monomeric E6AP-E6-p53 ternary complex
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8r1f
Q-score: 0.316
Sandate CR, Chakraborty D, Kater L, Kempf G, Thoma NH
bioRxiv (2023) [ DOI: doi:10.1101/2023.11.01.565136 ]
- Ubiquitin-like protein smt3,protein e6 (31 kDa, Protein from Human papillomavirus type 16)
- Zinc ion (65 Da, Ligand)
- Cellular tumor antigen p53 (46 kDa, Protein from Homo sapiens)
- Ubiquitin-protein ligase e3a (103 kDa, Protein from Homo sapiens)
- Monomeric e6ap-e6-p53 ternary complex (176 kDa, Complex from Homo sapiens)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8pm2
Q-score: 0.496
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG
bioRxiv (2023) [ Pubmed: 37461561 DOI: doi:10.1101/2023.07.07.547762 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- A complex of mouse trace-amine associated receptor 7f solubilized in lmng/chs bound to n,n-dimethylcyclohexylamine and coupled to: engineered guanine nucleotide-binding protein g(s) subunit alpha isoform short + guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 + guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 + nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Trace amine-associated receptor 7f (41 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
YAR027W and YAR028W in complex with c subunits from yeast VO complex
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 8eav
Q-score: 0.267
Wang H, Bueler SA, Rubinstein JL
PNAS (2023) 120 pp. e2217181120-e2217181120 [ Pubmed: 36724250 DOI: doi:10.1073/pnas.2217181120 ]
- Yar027w or yar028w (14 kDa, Protein from baker's yeast)
- Subunit from the c ring of yeast vo complex (13 kDa, Protein from baker's yeast)
- Yar027w or yar028w (15 kDa, Protein from baker's yeast)
- Yar027w or yar028w (14 kDa, Protein from baker's yeast)
- Yar027w or yar028w (15 kDa, Protein from baker's yeast)
- Yar027w or yar028w (13 kDa, Protein from baker's yeast)
- Yar027w or yar028w (13 kDa, Protein from baker's yeast)
- Yar027w and yar028w in complex with c subunits from yeast vo complex (Complex from Saccharomyces cerevisiae)
- Yar027w or yar028w (11 kDa, Protein from baker's yeast)
- Yar027w or yar028w (15 kDa, Protein from baker's yeast)
- Yar027w or yar028w (11 kDa, Protein from baker's yeast)
- Subunit from the c ring of yeast vo complex (12 kDa, Protein from baker's yeast)
Cryo-EM structure of SARS-CoV-2 ORF3a
Resolution: 2.08 Å
EM Method: Single-particle
Fitted PDBs: 7kjr
Q-score: 0.686
Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
Nat Struct Mol Biol (2021) 28 pp. 573-582 [ DOI: doi:10.1038/s41594-021-00619-0 Pubmed: 34158638 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Apolipoprotein a-i (24 kDa, Protein from Homo sapiens)
- Orf3a protein (32 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 protein 3a in lipid nanodiscs (62 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)