Cryo-EM structure of human gamma-secretase in complex with Abeta49
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x52
Q-score: 0.464
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ DOI: doi:10.1126/science.adn5820 Pubmed: 38843321 ]
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Human gamma-secretase in complex with abeta49 (Complex from Homo sapiens)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x53
Q-score: 0.509
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ DOI: doi:10.1126/science.adn5820 Pubmed: 38843321 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Amyloid-beta precursor protein (4 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta46 (Complex from Homo sapiens)
- Gamma-secretase subunit pen-2 (16 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x54
Q-score: 0.518
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ DOI: doi:10.1126/science.adn5820 Pubmed: 38843321 ]
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Human gamma-secretase in complex with app-c99 (Complex from Homo sapiens)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
cryo-EM structure of the DEAH-box helicase Prp2 in complex with its coactivator Spp2
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7dcr
Q-score: 0.49
Bai R, Wan R, Yan C, Jia Q, Lei J, Shi Y
Science (2021) 371 [ DOI: doi:10.1126/science.abe8863 Pubmed: 33243853 ]
- Prp2 isoform 1 (99 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor spp2 (20 kDa, Protein from Saccharomyces cerevisiae)
- Complex of atpase/helicase prp2 and its coactivator spp2 (119 MDa, Complex from Saccharomyces cerevisiae)
Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dd3
Q-score: 0.484
Bai R, Wan R, Yan C, Jia Q, Lei J, Shi Y
Science (2021) 371 [ DOI: doi:10.1126/science.abe8863 Pubmed: 33243853 ]
- The complex of pre-mrna-loaded deah-box atpase/helicase prp2 and its coactivator spp2 (Complex from Saccharomyces cerevisiae)
- Pre-mrna (2 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor spp2 (20 kDa, Protein from Saccharomyces cerevisiae)
- Prp2 isoform 1 (99 kDa, Protein from Saccharomyces cerevisiae)