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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND assembly_molecular_weight:{2000000 TO 5000000] AND electron_source:"FIELD EMISSION GUN" AND author_name:"Miotto MC"
Structure of PKA phosphorylated human RyR2-R420Q in the primed state
Release date: Nov. 22, 2023
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8uxc
Q-score: 0.466
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8uxc
Q-score: 0.466
To Be Published
Sample:
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420q and calstabin-2 (Complex)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
Release date: Nov. 22, 2023
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8uxe
Q-score: 0.391
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8uxe
Q-score: 0.391
To Be Published
Sample:
- Complex of ryr2-r420q and calstabin-2 in the presence of arm210 (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Structure of PKA phosphorylated human RyR2-R420W in the primed state
Release date: Nov. 22, 2023
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uxf
Q-score: 0.454
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uxf
Q-score: 0.454
To Be Published
Sample:
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
Release date: Nov. 22, 2023
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8uxg
Q-score: 0.434
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8uxg
Q-score: 0.434
To Be Published
Sample:
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
Release date: Nov. 22, 2023
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8uxh
Q-score: 0.366
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8uxh
Q-score: 0.366
To Be Published
Sample:
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
Release date: Nov. 22, 2023
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8uxi
Q-score: 0.39
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8uxi
Q-score: 0.39
To Be Published
Sample:
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-r420w and calstabin-2 (Complex)
Release date: Nov. 22, 2023
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8uxl
Q-score: 0.417
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8uxl
Q-score: 0.417
To Be Published
Sample:
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Calmodulin (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Release date: Nov. 22, 2023
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8uxm
Q-score: 0.381
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8uxm
Q-score: 0.381
To Be Published
Sample:
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Complex of ryr2-r420w, calstabin-2, and calmodulin (Complex)
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Structure of human RyR2-S2808D in the subprimed state
Release date: Nov. 15, 2023
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8uq2
Q-score: 0.443
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8uq2
Q-score: 0.443
To Be Published
Sample:
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-s2808d and calstabin-2 (Complex)
Structure of human RyR2-S2808D in the closed state in the presence of ARM210
Release date: Nov. 15, 2023
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8uq3
Q-score: 0.418
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8uq3
Q-score: 0.418
To Be Published
Sample:
- Peptidyl- cis-trans isomerase fkbp1b (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of ryr2-s2808d and calstabin-2 in the presence of arm210 (Complex)