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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND assembly_molecular_weight:{2000000 TO 5000000] AND electron_source:"FIELD EMISSION GUN" AND natural_source_ncbi_code:"10535"

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EMD-14146

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Structural organization of a late activated human spliceosome (Baqr, core region)

Release date: May 10, 2023
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qtt
Q-score: 0.384

Schmitzova J, Cretu C, Dienemann C, Urlaub H, Pena V

Nature (2023) 617 pp. 842-850 [ DOI: doi:10.1038/s41586-023-06049-w Pubmed: 37165190 ]

Sample:

Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
U2snrna (60 kDa, RNA from human)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Inositol hexakisphosphate (660 Da, Ligand)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
Late human activated spliceosome arrested with a dominant-negative mutant of the splicing helicase aquarius (aquarius k829a) (Complex from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Splicing factor 3a subunit 2 (49 kDa, Protein from human)
Splicing factor 3b subunit 1 (146 kDa, Protein from human)
Bud13 homolog (70 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from human)
G-patch domain and kow motifs-containing protein (52 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Splicing factor 3b subunit 2 (100 kDa, Protein from human)
Minx (102 kDa, RNA from unidentified adenovirus)
Splicing factor 3b subunit 3 (135 kDa, Protein from human)
U6snrna (34 kDa, RNA from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Splicing factor 3b subunit 4 (44 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Ring finger protein 113a (38 kDa, Protein from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Splicing factor 3b subunit 5 (10 kDa, Protein from human)
Splicing factor 3a subunit 3 (58 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
U5 snrna (37 kDa, RNA from human)

[Show more]

EMD-16658

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Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).

Release date: May 10, 2023
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 8ch6
Q-score: 0.154

Schmitzova J, Cretu C, Dienemann C, Urlaub H, Pena V

Nature (2023) 617 pp. 842-850 [ DOI: doi:10.1038/s41586-023-06049-w Pubmed: 37165190 ]

Sample:

U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Rnu5a-1 (37 kDa, RNA from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
Ring finger protein 113a (38 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Splicing factor 3b subunit 5 (10 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
Rnu2-1 (60 kDa, RNA from human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from human)
Splicing factor 3b subunit 4 (44 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Splicing factor 3b subunit 1 (146 kDa, Protein from human)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Late human activated spliceosome arrested with a dominant-negative mutant of the splicing helicase aquarius (aquarius k829a) (Complex from Homo sapiens)
Intron-binding protein aquarius (171 kDa, Protein from human)
G-patch domain and kow motifs-containing protein (52 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Splicing factor 3a subunit 3 (58 kDa, Protein from human)
Rnu6-1 (34 kDa, RNA from Homo sapiens)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from human)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from human)
Splicing factor 3a subunit 1 (88 kDa, Protein from human)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Minx-m3 (102 kDa, RNA from unidentified adenovirus)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Splicing factor 3b subunit 3 (135 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from human)
Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
Bud13 homolog (70 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Splicing factor 3b subunit 2 (100 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Splicing factor 3a subunit 2 (49 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)

[Show more]

EMD-32317

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The cryo-EM structure of human pre-C*-I complex

Release date: June 22, 2022
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w59
Q-score: 0.268

Zhan X, Lu Y, Zhang X, Yan C, Shi Y

Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]

Sample:

U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
U6 snrna (34 kDa, RNA from Human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Psme3-interacting protein (28 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
Human pre-c*-i complex (Complex from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Pre-mrna (55 kDa, RNA from unidentified adenovirus)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Rna helicase aquarius (171 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
U5 snrna (37 kDa, RNA from human)
Pre-mrna (14 kDa, RNA from unidentified adenovirus)
Zinc ion (65 Da, Ligand)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Protein casc3 (76 kDa, Protein from human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)

[Show more]

EMD-32319

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The cryo-EM structure of human pre-C*-II complex

Release date: June 22, 2022
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w5a
Q-score: 0.269

Zhan X, Lu Y, Zhang X, Yan C, Shi Y

Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]

Sample:

U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
Cactin (88 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pre-mrna (55 kDa, RNA from unidentified adenovirus)
Human pre-c*-ii complex (Complex from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Psme3-interacting protein (28 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Rna helicase aquarius (171 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
U5 snrna (37 kDa, RNA from human)
U6 snrna (34 kDa, RNA from human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Zinc ion (65 Da, Ligand)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Prkr-interacting protein 1 (21 kDa, Protein from human)
Pre-mrna (14 kDa, RNA from unidentified adenovirus)
Protein bud31 homolog (17 kDa, Protein from human)
Protein fam32a (13 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Protein casc3 (76 kDa, Protein from human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)

[Show more]

EMD-32321

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The cryo-EM structure of human C* complex

Release date: June 22, 2022
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7w5b
Q-score: 0.192

Zhan X, Lu Y, Zhang X, Yan C, Shi Y

Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]

Sample:

Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
Pre-mrna (14 kDa, RNA from unidentified adenovirus)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Cactin (88 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
U6 snrna (34 kDa, RNA from human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Protein casc3 (76 kDa, Protein from human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Rna helicase aquarius (171 kDa, Protein from human)
Prkr-interacting protein 1 (21 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
Protein fam32a (13 kDa, Protein from human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Nf-kappa-b-activating protein (47 kDa, Protein from human)
Human pre-c*-i complex (Complex from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna (55 kDa, RNA from unidentified adenovirus)
U5 snrna (37 kDa, RNA from human)

[Show more]

Sort by: Download

Showing 1 - 5 of 5. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [5]

Format:

Select the script type:

Shell (Unix-based) Batch (Windows-based)

Preview first 10

Field: