Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7syd
Q-score: 0.481
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
eLife (2021) 10 [ Pubmed: 34846302 DOI: doi:10.7554/eLife.73218 ]
- Epidermal growth factor receptor (134 kDa, Protein from Homo sapiens)
- Epidermal growth factor (6 kDa, Protein from Homo sapiens)
- Full-length human egfr:egf complex (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sz0
Q-score: 0.463
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
eLife (2021) 10 [ Pubmed: 34846302 DOI: doi:10.7554/eLife.73218 ]
- Epidermal growth factor receptor (134 kDa, Protein from Homo sapiens)
- Full-length human egfr(l834r):egf complex (Complex)
- Epidermal growth factor (6 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sz1
Q-score: 0.413
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
eLife (2021) 10 [ Pubmed: 34846302 DOI: doi:10.7554/eLife.73218 ]
- Full-length human egfr(l834r):egf complex (Complex)
- Epidermal growth factor (6 kDa, Protein from Homo sapiens)
- Epidermal growth factor receptor (134 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sz5
Q-score: 0.41
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
eLife (2021) 10 [ Pubmed: 34846302 DOI: doi:10.7554/eLife.73218 ]
- Full-length human egfr:tgf-alpha complex (Complex from Homo sapiens)
- Epidermal growth factor receptor (134 kDa, Protein from Homo sapiens)
- Transforming growth factor alpha (5 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sz7
Q-score: 0.429
Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
eLife (2021) 10 [ Pubmed: 34846302 DOI: doi:10.7554/eLife.73218 ]
- Epidermal growth factor receptor (134 kDa, Protein from Homo sapiens)
- Transforming growth factor alpha (5 kDa, Protein from Homo sapiens)
- Full-length human egfr:tgf-alpha complex (Complex from Homo sapiens)
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7pw4
Q-score: 0.495
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ DOI: doi:10.7554/eLife.72353 Pubmed: 34698635 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1 (397 kDa, Protein from Homo sapiens)
Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7pw5
Q-score: 0.357
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ DOI: doi:10.7554/eLife.72353 Pubmed: 34698635 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1 (397 kDa, Protein from Homo sapiens)
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7pw6
Q-score: 0.539
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ DOI: doi:10.7554/eLife.72353 Pubmed: 34698635 ]
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1 (320 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
Human SMG1-9 kinase complex bound to a SMG1 inhibitor
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7pw7
Q-score: 0.416
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ DOI: doi:10.7554/eLife.72353 Pubmed: 34698635 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
- Smg1-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1 (397 kDa, Protein from Homo sapiens)
Human SMG1-8-9 kinase complex bound to AMPPNP
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 7pw8
Q-score: 0.558
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ Pubmed: 34698635 DOI: doi:10.7554/eLife.72353 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1 (397 kDa, Protein from Homo sapiens)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Smg1-smg8-smg9 kinase complex bound to amppnp (597 kDa, Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)