Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8hrx
Q-score: 0.523
Asami J, Park JH, Nomura Y, Kobayashi C, Mifune J, Ishimoto N, Uemura T, Liu K, Sato Y, Zhang Z, Muramatsu M, Wakita T, Drew D, Iwata S, Shimizu T, Watashi K, Park SY, Nomura N, Ohto U
Nat Struct Mol Biol (2024) 31 pp. 447-454 [ Pubmed: 38233573 DOI: doi:10.1038/s41594-023-01191-5 ]
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab heavy chain from antibody igg clone number yn9048 (26 kDa, Protein from Ondatra zibethicus)
- Fab light chain from antibody igg clone number yn9048 (23 kDa, Protein from Ondatra zibethicus)
- Pres1 protein (fragment) (6 kDa, Protein from Hepatitis B virus)
- Ntcp-myr-pres1-yn9048fab (Complex from Homo sapiens)
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8hry
Q-score: 0.523
Asami J, Park JH, Nomura Y, Kobayashi C, Mifune J, Ishimoto N, Uemura T, Liu K, Sato Y, Zhang Z, Muramatsu M, Wakita T, Drew D, Iwata S, Shimizu T, Watashi K, Park SY, Nomura N, Ohto U
Nat Struct Mol Biol (2024) 31 pp. 447-454 [ Pubmed: 38233573 DOI: doi:10.1038/s41594-023-01191-5 ]
- Fab heavy chain from antibody igg clone number yn9016 (25 kDa, Protein from Ondatra zibethicus)
- Ntcp-myr-pres1-yn9016fab (Complex from Homo sapiens)
- Fab light chain from antibody igg clone number yn9016 (23 kDa, Protein from Ondatra zibethicus)
- Large s protein (fragment) (6 kDa, Protein from Hepatitis B virus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
Structure of bile acid transporter NTCP
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) [ DOI: 10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
Image sets:
- Raw movies for Human NTCP (Q261A) - YN69202Fab-myr-preS1 (EMD-31840, PDB 7VAF)
- Raw movies for Rat NTCP (Q261A) - YN69202Fab (EMD-31839, PDB 7VAE)
- Raw movies for Human NTCP (wildtype) - YN69202Fab (EMD-32759, PDB 7WSI)
- Raw movies for Human NTCP (Q261A) - YN69202Fab (EMD-31837, PDB 7VAD)
- Raw movies for Bovine NTCP (Q261A) - YN69202Fab (EMD-31838, PDB 7VAE)
Cryo-EM structure of human NTCP complexed with YN69202Fab
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7vad
Q-score: 0.399
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Ntcp: (Complex from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Fab (Complex)
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7vae
Q-score: 0.4
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ Pubmed: 35580629 DOI: doi:10.1038/s41586-022-04845-4 ]
- Complex of ntcp and fab (Complex from Homo sapiens)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (38 kDa, Protein from Bos taurus)
- Ntcp (Complex from Mus musculus)
- Fab (Complex)
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7vaf
Q-score: 0.461
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ Pubmed: 35580629 DOI: doi:10.1038/s41586-022-04845-4 ]
- Fab (Complex from Rattus norvegicus)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Complex of ntcp and fab (Complex from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Rattus norvegicus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Ntcp (Complex)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7vag
Q-score: 0.401
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Complex of ntcp and fab in the presence of myristoylated pres1 peptide (Complex from Homo sapiens)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Ntcp (Complex from Mus musculus)
- Fab (Complex)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7wsi
Q-score: 0.434
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Ntcp (Complex from Homo sapiens)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Fab (Complex)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of human TLR3 in complex with UNC93B1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7c76
Q-score: 0.437
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol (2021) 28 pp. 173-180 [ Pubmed: 33432245 DOI: doi:10.1038/s41594-020-00542-w ]
- Toll-like receptor 3 (103 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein unc-93 homolog b1 (66 kDa, Protein from Homo sapiens)
- Complex of tlr3 and unc93b1 (Complex from Homo sapiens)
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7c77
Q-score: 0.424
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol (2021) 28 pp. 173-180 [ Pubmed: 33432245 DOI: doi:10.1038/s41594-020-00542-w ]
- Toll-like receptor 3 (103 kDa, Protein from Mus musculus)
- Protein unc-93 homolog b1 (67 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of tlr3 and unc93b1 (Complex from Mus musculoides)