Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ubr
Q-score: 0.61
Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J
PNAS (2024) 121 pp. e2316675121-e2316675121 [ DOI: doi:10.1073/pnas.2316675121 Pubmed: 38422021 ]
- 4-[(z)-{(3m)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid (409 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Complex of cftr with the small molecule inhibitor cftrinh-172 (168 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8fzq
Q-score: 0.351
Levring J, Terry DS, Kilic Z, Fitzgerald G, Blanchard S, Chen J
Nature (2023) 616 pp. 606-614 [ Pubmed: 36949202 DOI: doi:10.1038/s41586-023-05854-7 ]
- Dephosphorylated, atp-bound human cystic fibrosis transmembrane conductance regulator (cftr) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6uy0
Q-score: 0.515
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S
eLife (2020) 9 [ Pubmed: 32458799 DOI: doi:10.7554/eLife.56451 ]
- Multidrug resistance-associated protein 1 (172 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) (170 kDa, Complex from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6o1v
Q-score: 0.482
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ DOI: doi:10.1126/science.aaw7611 Pubmed: 31221859 ]
- N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5h-thieno[2,3-c]pyran-2-yl)-1h-pyrazole-3-carboxamide (348 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of human cystic fibrosis transmembrane conductance regulator (cftr) and glpg1837 (168 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6o2p
Q-score: 0.46
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ Pubmed: 31221859 DOI: doi:10.1126/science.aaw7611 ]
- N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (392 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Complex of ivacaftor and cystic fibrosis transmembrane conductance regulator (cftr) (168 kDa, Complex from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)