Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8f0s
Q-score: 0.614
Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84151 Pubmed: 36975198 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha chimera (184 kDa, Protein from Homo sapiens)
- 5-chloro-4-(cyclopentylmethoxy)-n-(4-{[(1s,2s)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonyl)-2-fluorobenzamide (570 Da, Ligand)
- Beta-diguetoxin-dc1a (8 kDa, Protein from Diguetia canities)
- Vsd4-nav1.7-navpas channel chimera bound to the hybrid inhibitor gne-9296 (Complex from Homo sapiens)
The structure of FC08 Fab-hA.CE2-RBD complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7dx4
Q-score: 0.425
Zhang L, Cao L, Gao XS, Zheng BY, Deng YQ, Li JX, Feng R, Bian Q, Guo XL, Wang N, Qiu HY, Wang L, Cui Z, Ye Q, Chen G, Lu KK, Chen Y, Chen YT, Pan HX, Yu J, Yao W, Zhu BL, Chen J, Liu Y, Qin CF, Wang X, Zhu FC
Natl Sci Rev (2021) 8 pp. nwab053-nwab053 [ DOI: doi:10.1093/nsr/nwab053 Pubmed: 34676098 ]
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (Complex from Homo sapiens)
- Heavy chain of fc08 fab (13 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 (Complex from Homo sapiens)
- Fc08 fab (Complex)
- Light chain of fc08 fab (11 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of amyloid fibril formed by full-length human prion protein
Resolution: 2.702 Å
EM Method: Helical reconstruction
Fitted PDBs: 6lni
Q-score: 0.606
Wang LQ, Zhao K, Yuan HY, Wang Q, Guan Z, Tao J, Li XN, Sun Y, Yi CW, Chen J, Li D, Zhang D, Yin P, Liu C, Liang Y
Nat Struct Mol Biol (2020) 27 pp. 598-602 [ Pubmed: 32514176 DOI: doi:10.1038/s41594-020-0441-5 ]
- Human prion protein amyloid fibril (Cellular component from Homo sapiens)
- Major prion protein (22 kDa, Protein from Homo sapiens)
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6agf
Q-score: 0.526
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (2018) 362 [ Pubmed: 30190309 DOI: doi:10.1126/science.aau2486 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 4 subunit alpha (212 kDa, Protein from Homo sapiens)
- N-acetyl-d-glucosamine (221 Da, Ligand)
- Complex of human sodium channel protein type 4 subunit alpha and human sodium channel subunit beta-1 (200 kDa, Complex)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Human sodium channel protein type 4 subunit alpha (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Beta-d-mannose (180 Da, Ligand)
- Human sodium channel subunit beta-1 (Complex from Homo sapiens)