Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8gls
Q-score: 0.442
Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Irwin JJ, Gmeiner P, Shoichet BK, Chen J
To Be Published
- Cftr (Cellular component from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-1-(3-amino-6-fluoro-1h-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one (313 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human cystic fibrosis transmembrane conductance regulator (1 kDa, Protein from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 9-mer peptide ILKEPVHGV
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide ilkepvhgv (156 kDa, Complex from Homo sapiens)
- Transframe peptide (993 Da, Protein from Human immunodeficiency virus 1)
Transporter associated with antigen processing (TAP) bound to the 9-mer peptide RRYQKSTEL
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Histone h3.3c peptide (1 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide rryqkstel (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 9-mer peptide QYDDAVYKL
To Be Published
- Hla-c4 specific peptide (1 kDa, Protein from synthetic construct)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide qyddavykl (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 8-mer peptide RRYQSTEL
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Synthetic 8-mer peptide (1 kDa, Protein from synthetic construct)
- Transporter associated with antigen processing bound to the 8-mer peptide rryqstel (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 14-mer peptide lpavvglspgeqey (156 kDa, Complex from Homo sapiens)
- Hla-b35 specific peptide (1 kDa, Protein from synthetic construct)
Transporter associated with antigen processing (TAP) in the apo state
Lee J, Oldham ML, Manon V, Chen J
PNAS (2024) 121 pp. e2320879121-e2320879121 [ DOI: doi:10.1073/pnas.2320879121 Pubmed: 38805290 ]
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing (156 kDa, Complex from Homo sapiens)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)