Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Chen J" AND author_orcid:"0000-0002-3152-2237" AND sample_type:"complex" AND xref_links:"chembl" AND software_ft:"CRYOSPARC"

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EMD-33748

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Spike_GSAS_6P protomer RBD domain bound with R1-32 Fab and ACE2 with 3:3:3 ratio

Release date: Aug. 24, 2022
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 7ydi
Q-score: 0.296

He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X

Nat Microbiol (2022) 7 pp. 1635-1649 [ DOI: doi:10.1038/s41564-022-01235-4 Pubmed: 36151403 ]

Sample:

2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
Ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
Sars-cov-2 s-gsas/6p spike trimer (Complex from Homo sapiens)
Heavy chain of r1-32 (23 kDa, Protein from Homo sapiens)
Sars-cov-2 s-gsas/6p spike trimer bound to r1-32 fab with 3:1 ratio (Complex from Homo sapiens)
R1-32 fab (Complex)
Zinc ion (65 Da, Ligand)
Light chain of r1-32 (22 kDa, Protein from Homo sapiens)
Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)

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