Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8eig
Q-score: 0.506
Science (2022) 378 pp. 284-290 [ Pubmed: 36264792 DOI: doi:10.1126/science.ade2216 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- (6p)-n-(1,3-dimethyl-1h-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1h-pyrazol-1-yl]-2-[(4s)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (597 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- The complex of phosphorylated human delta f508 cystic fibrosis transmembrane conductance regulator (cftr) with elexacaftor (vx-445) and atp/mg (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8eio
Q-score: 0.579
Science (2022) 378 pp. 284-290 [ Pubmed: 36264792 DOI: doi:10.1126/science.ade2216 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (1 kDa, Protein from Homo sapiens)
- The complex of phosphorylated human delta f508 cystic fibrosis transmembrane conductance regulator (cftr) with elexacaftor (vx-445), lumacaftor (vx-809) and atp/mg (168 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- (6p)-n-(1,3-dimethyl-1h-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1h-pyrazol-1-yl]-2-[(4s)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (597 Da, Ligand)
- Lumacaftor (452 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8eiq
Q-score: 0.583
Science (2022) 378 pp. 284-290 [ DOI: doi:10.1126/science.ade2216 Pubmed: 36264792 ]
- Tezacaftor (520 Da, Ligand)
- (6p)-n-(1,3-dimethyl-1h-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1h-pyrazol-1-yl]-2-[(4s)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (597 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (392 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- The complex of phosphorylated human delta f508 cystic fibrosis transmembrane conductance regulator (cftr) with trikafta [elexacaftor (vx-445), tezacaftor (vx-661), ivacaftor (vx-770)] and atp/mg (168 kDa, Complex from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator (1 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Dephosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 6.9 Å
EM Method: Single-particle
Fitted PDBs: 8ej1
Q-score: 0.334
Science (2022) 378 pp. 284-290 [ DOI: doi:10.1126/science.ade2216 Pubmed: 36264792 ]