Transporter associated with antigen processing (TAP) bound to the 9-mer peptide ILKEPVHGV
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide ilkepvhgv (156 kDa, Complex from Homo sapiens)
- Transframe peptide (993 Da, Protein from Human immunodeficiency virus 1)
Transporter associated with antigen processing (TAP) bound to the 9-mer peptide RRYQKSTEL
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Histone h3.3c peptide (1 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide rryqkstel (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 9-mer peptide QYDDAVYKL
To Be Published
- Hla-c4 specific peptide (1 kDa, Protein from synthetic construct)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 9-mer peptide qyddavykl (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 8-mer peptide RRYQSTEL
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Synthetic 8-mer peptide (1 kDa, Protein from synthetic construct)
- Transporter associated with antigen processing bound to the 8-mer peptide rryqstel (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 7-mer peptide RRYSTEL
To Be Published
- Synthetic 7-mer peptide (926 Da, Protein from synthetic construct)
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 7-mer peptide rrystel (156 kDa, Complex from Homo sapiens)
Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY
To Be Published
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing bound to the 14-mer peptide lpavvglspgeqey (156 kDa, Complex from Homo sapiens)
- Hla-b35 specific peptide (1 kDa, Protein from synthetic construct)
Transporter associated with antigen processing (TAP) in the apo state
Lee J, Oldham ML, Manon V, Chen J
PNAS (2024) 121 pp. e2320879121-e2320879121 [ DOI: doi:10.1073/pnas.2320879121 Pubmed: 38805290 ]
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Transporter associated with antigen processing (156 kDa, Complex from Homo sapiens)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ubr
Q-score: 0.61
Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J
PNAS (2024) 121 pp. e2316675121-e2316675121 [ DOI: doi:10.1073/pnas.2316675121 Pubmed: 38422021 ]
- 4-[(z)-{(3m)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid (409 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Complex of cftr with the small molecule inhibitor cftrinh-172 (168 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8fzq
Q-score: 0.351
Levring J, Terry DS, Kilic Z, Fitzgerald G, Blanchard S, Chen J
Nature (2023) 616 pp. 606-614 [ Pubmed: 36949202 DOI: doi:10.1038/s41586-023-05854-7 ]
- Dephosphorylated, atp-bound human cystic fibrosis transmembrane conductance regulator (cftr) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8eig
Q-score: 0.506
Science (2022) 378 pp. 284-290 [ Pubmed: 36264792 DOI: doi:10.1126/science.ade2216 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- (6p)-n-(1,3-dimethyl-1h-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1h-pyrazol-1-yl]-2-[(4s)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (597 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- The complex of phosphorylated human delta f508 cystic fibrosis transmembrane conductance regulator (cftr) with elexacaftor (vx-445) and atp/mg (Complex from Homo sapiens)