Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ Pubmed: 38744983 DOI: doi:10.1038/s41422-024-00968-7 ]
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (75 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex of succinate receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
Cryo-EM structure of human Cav3.2 with ML218
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayk
Q-score: 0.519
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- 3,5-dichloro-n-{[(1r,5s,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide (369 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ACT-709478
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ayl
Q-score: 0.531
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- N-{1-[(5-cyanopyridin-2-yl)methyl]-1h-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide (425 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
The resting state of yeast proteasome
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 5wvi
Q-score: 0.14
Ding Z, Fu Z, Xu C, Wang Y, Wang Y, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y
Cell Res (2017) 27 pp. 373-385 [ Pubmed: 28106073 DOI: doi:10.1038/cr.2017.12 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Baker's yeast)
- 26s protease subunit rpt4 (49 kDa, Protein from Baker's yeast)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Baker's yeast)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Baker's yeast)
- 26s protease regulatory subunit 6a (48 kDa, Protein from Baker's yeast)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from Baker's yeast)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Baker's yeast)
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-2 (28 kDa, Protein from Baker's yeast)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Baker's yeast)
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-5 (31 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-7 (29 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-4 (22 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-6 (26 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-3 (22 kDa, Protein from Baker's yeast)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Baker's yeast)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Baker's yeast)
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from Baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Baker's yeast)
- The yeast resting state proteasome (1 MDa, Complex from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from Baker's yeast)
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Baker's yeast)
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Baker's yeast)
- Proteasome subunit beta type-1 (23 kDa, Protein from Baker's yeast)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5wvk
Q-score: 0.169
Ding Z, Fu Z, Xu C, Wang Y, Wang Y, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y
Cell Res (2017) 27 pp. 373-385 [ Pubmed: 28106073 DOI: doi:10.1038/cr.2017.12 ]
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Yeast proteasome in complex with adp-alfx (1 MDa, Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))