Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6o1v
Q-score: 0.482
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ DOI: doi:10.1126/science.aaw7611 Pubmed: 31221859 ]
- N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5h-thieno[2,3-c]pyran-2-yl)-1h-pyrazole-3-carboxamide (348 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of human cystic fibrosis transmembrane conductance regulator (cftr) and glpg1837 (168 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6o2p
Q-score: 0.46
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ Pubmed: 31221859 DOI: doi:10.1126/science.aaw7611 ]
- N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (392 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Complex of ivacaftor and cystic fibrosis transmembrane conductance regulator (cftr) (168 kDa, Complex from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 4.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 6e9y
Q-score: 0.298
Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D
Science (2018) 362 pp. 705-709 [ Pubmed: 30409885 DOI: doi:10.1126/science.aau3775 ]
- Dhf38 filament (25 kDa, Protein from synthetic construct)
- Dhf38 filament (Complex from synthetic construct)
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c0v
Q-score: 0.433
Science (2018) 359 pp. 915-919 [ DOI: doi:10.1126/science.aar7389 Pubmed: 29371429 ]
- Human p-glycoprotein e556q, e1201q (141 kDa, Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Multidrug resistance protein 1 (142 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 6bhu
Q-score: 0.461
Cell (2018) 172 pp. 81-89.e10 [ Pubmed: 29290467 DOI: doi:10.1016/j.cell.2017.12.005 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Multidrug resistance-associated protein 1 (183 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) e1454q (170 kDa, Complex from Bos taurus)
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 5w81
Q-score: 0.34
Cell (2017) 170 pp. 483-491.e8 [ DOI: doi:10.1016/j.cell.2017.06.041 Pubmed: 28735752 ]
- Zebrafish cystic fibrosis transmembrane conductance regulator (cftr) (168 MDa, Complex from Danio rerio)
- Magnesium ion (24 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Danio rerio)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1)
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 5uj9
Q-score: 0.396
Cell (2017) 168 pp. 1075-1085.e9 [ DOI: doi:10.1016/j.cell.2017.01.041 Pubmed: 28238471 ]
Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 5uja
Q-score: 0.372
Cell (2017) 168 pp. 1075-1085.e9 [ Pubmed: 28238471 DOI: doi:10.1016/j.cell.2017.01.041 ]
- Bovine multidrug resistance protein 1 (mrp1),multidrug resistance-associated protein 1 (159 kDa, Protein from Bos taurus)
- (5~{s},6~{r},7~{e},9~{e},11~{z},14~{z})-6-[(2~{r})-2-[[(4~{s})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid (625 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) complexed with leukotriene c4 (170 kDa, Complex from Bos taurus)
Cryo-EM structure of the human TAP ATP-Binding Cassette Transporter
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 5u1d
Q-score: 0.292
Oldham ML, Grigorieff N, Chen J
eLife (2016) 5 [ Pubmed: 27935481 DOI: doi:10.7554/eLife.21829 ]
- Tap atp-binding cassette transporter (Complex from Homo sapiens)
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Tap transporter inhibitor icp47 (9 kDa, Protein from Human herpesvirus 1)
Structure of human cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 5uak
Q-score: 0.326
Cell (2016) 167 pp. 1586-1597.e9 [ DOI: doi:10.1016/j.cell.2016.11.014 Pubmed: 27912062 ]