Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6o1v
Q-score: 0.482
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ DOI: doi:10.1126/science.aaw7611 Pubmed: 31221859 ]
- N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5h-thieno[2,3-c]pyran-2-yl)-1h-pyrazole-3-carboxamide (348 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of human cystic fibrosis transmembrane conductance regulator (cftr) and glpg1837 (168 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6o2p
Q-score: 0.46
Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Science (2019) 364 pp. 1184-1188 [ Pubmed: 31221859 DOI: doi:10.1126/science.aaw7611 ]
- N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (392 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (169 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Complex of ivacaftor and cystic fibrosis transmembrane conductance regulator (cftr) (168 kDa, Complex from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c0v
Q-score: 0.433
Science (2018) 359 pp. 915-919 [ DOI: doi:10.1126/science.aar7389 Pubmed: 29371429 ]
- Human p-glycoprotein e556q, e1201q (141 kDa, Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Multidrug resistance protein 1 (142 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of the human TAP ATP-Binding Cassette Transporter
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 5u1d
Q-score: 0.292
Oldham ML, Grigorieff N, Chen J
eLife (2016) 5 [ Pubmed: 27935481 DOI: doi:10.7554/eLife.21829 ]
- Tap atp-binding cassette transporter (Complex from Homo sapiens)
- Antigen peptide transporter 2 (75 kDa, Protein from Homo sapiens)
- Antigen peptide transporter 1 (81 kDa, Protein from Homo sapiens)
- Tap transporter inhibitor icp47 (9 kDa, Protein from Human herpesvirus 1)
Structure of human cystic fibrosis transmembrane conductance regulator (CFTR)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 5uak
Q-score: 0.326
Cell (2016) 167 pp. 1586-1597.e9 [ DOI: doi:10.1016/j.cell.2016.11.014 Pubmed: 27912062 ]