Human Nav1.8 with A-803467, class I
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7we4
Q-score: 0.55
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel i (Complex from Homo sapiens)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
Human Nav1.8 with A-803467, class II
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7wel
Q-score: 0.487
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ Pubmed: 35858452 DOI: doi:10.1073/pnas.2208211119 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Sodium channel ii (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Human Nav1.8 with A-803467, class III
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wfr
Q-score: 0.483
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ Pubmed: 35858452 DOI: doi:10.1073/pnas.2208211119 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 5-(4-chlorophenyl)-~{n}-(3,5-dimethoxyphenyl)furan-2-carboxamide (357 Da, Ligand)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)
- Sodium channel iii (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wfw
Q-score: 0.471
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
PNAS (2022) 119 pp. e2208211119-e2208211119 [ DOI: doi:10.1073/pnas.2208211119 Pubmed: 35858452 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel ii (Complex from Homo sapiens)
- Sodium channel protein type 10 subunit alpha (220 kDa, Protein from Homo sapiens)