Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
hOCT1 in complex with metformin in outward open conformation
hOCT1 in complex with metformin in outward occluded conformation
hOCT1 in complex with metformin in inward occluded conformation
hOCT1 in complex with nb5660 in inward facing partially open 1 conformation